Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage
December 2010
in “
The journal of investigative dermatology/Journal of investigative dermatology
”
induced pluripotent stem cells iPSCs keratinocyte lineage retinoic acid bone-morphogenetic protein-4 collagen IV epidermis hair follicles sebaceous glands gene expression protein expression primary keratinocytes in vitro differentiation in vivo reconstitution genetically corrected autologous iPSCs stem cells BMP-4 skin cells collagen skin hair oil glands gene activity protein activity lab-grown skin cells live organism skin regeneration corrected stem cells
Studysummary This study reports the successful differentiation of mouse induced pluripotent stem cells into keratinocytes that can regenerate skin and its structures in an in vivo environment.
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