New Fluorogenic Probes for Neutral and Alkaline Ceramidases

    March 2019 in “ Journal of lipid research ”
    Mireia Casasampere, Núria Bielsa, Daniel Riba … Josefina Casas
    Studysummary This study reports new fluorogenic ceramidase substrates and highlights RBM14C24:1 as an efficient substrate for neutral ceramidase, while RBM15C18:1 is the best probe for measuring ACER1 and ACER2 activities, potentially aiding high-throughput screening for ceramidase inhibitors.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on jlr.org →
    Discuss this study in the Community →

    Research cited in this study 2

    1. Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells Stem Cell Reports · 2017
    2. Alkaline Ceramidase 1 Is Essential for Mammalian Skin Homeostasis and Regulating Whole-Body Energy Expenditure The Journal of Pathology · 2016