Bioactive Proteolytic Enzymes Chymotrypsin and Papain as Adjuvants to Laser Hair Removal: Reducing the Risk of Paradoxical Hypertrichosis in Women with Facial Hirsutism

    March 2026 in “ Cosmetics ”
    Aikaterini Liatsopoulou, Athanasia Varvaresou, Evangelia Protopapa
    Studysummary This study found that combining Alexandrite laser with iontophoresis of chymotrypsin and papain enzymes reduced the laser pulse requirements compared to laser alone for treating paradoxical hypertrichosis in women with facial hirsutism, suggesting potential clinical benefits in managing this condition.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 6

    1. What Are the Factors That Induce Paradoxical Hypertrichosis After Laser Hair Removal? Aesthetic Surgery Journal · 2024
    2. Proteolytic Enzymes Papain and Chymotrypsin Combined with Laser Techniques for the Management of Facial Hirsutism Planta Medica · 2022
    3. Principles of Management of Women with Hirsutism: A Dermatologist’s Perspective Przegla̧d dermatologiczny · 2020
    4. Evaluation of Topical Capislow Extract and Long Pulsed Nd-YAG Laser in the Treatment of Idiopathic Hirsutism Journal of lasers in medical sciences · 2018
    5. The Hair Follicle: An Underutilized Source of Cells and Materials for Regenerative Medicine ACS biomaterials science & engineering · 2017
    6. Histological Evaluation of Hair Follicle Due to Papain's Depilatory Effect International journal of pharmaceutics · 2007