Proteolytic Enzymes Papain and Chymotrypsin Combined with Laser Techniques for the Management of Facial Hirsutism

This study investigated the effectiveness of combining laser treatment with iontophoresis of proteolytic enzymes papain and chymotrypsin for managing facial hirsutism in 30 adult Caucasian women. Participants were divided into two groups: one received both laser Alexandrite 755 nm and enzyme iontophoresis, while the other received only the laser treatment. Results showed that the group receiving the combined treatment experienced a significantly greater reduction in hair count over 6 months compared to the laser-only group (p = 0.017). The study concludes that the iontophoretic delivery of papain and chymotrypsin can enhance the efficacy of laser treatments for hirsutism, offering a more natural adjuvant approach.