Demonstrating the Potential of Untargeted Hair Proteomics for Personalized Biomarkers in Stress-Associated Disorders

    November 2025 in “ Psychoneuroendocrinology ”
    Maurizio Sicorello, Jeanne-Carla Sprenger, Lisa Störkel … Alexander Karabatsiakis
    Studysummary This study reported that machine learning analysis of protein profiles in hair segments achieved high accuracy in distinguishing women with non-suicidal self-injury disorder from healthy controls, suggesting hair proteomics as a promising non-invasive biomarker for stress-related psychopathology with potential clinical applications.
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    Research cited in this study 2

    1. Protein Extraction from Human Anagen Head Hairs 1 Millimeter or Less in Total Length Biotechniques/BioTechniques · 2018
    2. Hair as a Retrospective Calendar of Cortisol Production—Increased Cortisol Incorporation into Hair in the Third Trimester of Pregnancy Psychoneuroendocrinology · 2008