Androgenic Modulation of Arterial Baroreceptor Dysfunction and Neuroinflammation in Endotoxic Male Rats

February 2021 in “ Brain Research ”

Marwa Ahmed Sallam, Sahar M. El-Gowilly, Mahmoud M. El-Mas

androgenic hormones testosterone lipopolysaccharide LPS baroreflex sensitivity neuroinflammation castration testosterone replacement phenylephrine sodium nitroprusside degarelix gonadotropin-releasing hormone receptor blocker dihydrotestosterone DHT estrogen hypothalamic-pituitary-gonadal axis endotoxemia

Studysummary This study found that testosterone replacement in castrated male rats counteracted endotoxemia-induced arterial baroreflex dysfunction without significantly affecting neuroinflammation.

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