Features of the Immune Status and Comorbidities in Children With Alopecia Areata
November 2023
in “
Medical Immunology (Russia)
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New to Alopecia Areata? There is a guide in the encyclopedia. Read the guide → alopecia areata immune status comorbidities common variable immunodeficiency chronic tonsillitis allergic rhinitis autoimmune thyroiditis CD3 + CD4 + cells immunoglobulins IgA IgM IgG interleukins IL-4 IL-6 immune hyperfunction immune deficiency phagocytic activity immune system imbalance immune dysregulation
Studysummary In this study, researchers found that children with alopecia areata exhibited immune system imbalances, including increased autoimmune and allergic markers and decreased phagocytic activity, along with a higher prevalence of autoimmune thyroiditis and allergic rhinitis compared to children without alopecia.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study investigated the immune status and comorbidities in 57 children with alopecia areata compared to 157 without the condition. It found that children with alopecia had a higher prevalence of the focal form of the disease and were more likely to have common variable immunodeficiency, chronic tonsillitis, allergic rhinitis, and autoimmune thyroiditis. These children exhibited immune system imbalances, including elevated levels of CD3 + CD4 + cells, immunoglobulins (IgA, IgM, IgG), and interleukins (IL-4, IL-6), indicating immune hyperfunction typical of autoimmune and allergic processes. Additionally, they showed reduced phagocytic activity, suggesting immune deficiency. These findings highlight the complex immune dysregulation in children with alopecia areata.
