211 citations
,
April 2013 in “Development” In this study, researchers found that the number of dermal papilla cells in hair follicles determines hair size and shape in mice, suggesting potential avenues for addressing hair loss.
156 citations
,
October 2012 in “Seminars in Cell & Developmental Biology” This study found that hair follicle stem cells initially contribute to wound re-epithelialization, but long-lasting epidermal cells are primarily derived from a stem cell population in the isthmus portion of hair follicles.
305 citations
,
June 2012 in “Nature” This study reports that hair regeneration in live mice involves spatially regulated stem cell divisions and requires mesenchymal interactions, observed in real-time using a novel non-invasive imaging method.
63 citations
,
April 2010 in “Development” This article discusses the bi-compartmental organization of hair follicle stem cell niches for balancing stem cell cycling and organ growth and proposes similar structures may exist in other adult stem cell niches but reports no new experimental results.
351 citations
,
February 2010 in “Nature Cell Biology” Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.
1201 citations
,
January 2010 in “Science” This review discusses stem cells in the hair follicle, bone marrow, and intestinal epithelium and introduces a model where quiescent and cycling stem cells may coexists in "zoned" configurations.
835 citations
,
October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
1279 citations
,
November 2005 in “Nature Medicine”
291 citations
,
October 2005 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that rat whisker follicle stem cells can be expanded in culture and transplanted to form functional hair follicles, demonstrating their multipotency and potential for regenerative medicine.
417 citations
,
September 2005 in “PLoS biology” This study developed molecular signatures for dermal papilla cells and their niche, uncovering novel signaling regulators and genes linked to hair disorders, which may inform future hair development research.
387 citations
,
November 2003 in “Journal of Investigative Dermatology” The K15 promoter effectively targets stem cells in the hair follicle bulge.
561 citations
,
April 2003 in “Journal of Investigative Dermatology” CD34 is a marker for isolating stem-like cells in mouse hair follicles.
215 citations
,
November 2000 in “Journal of Investigative Dermatology” This study found that the tetracycline-regulated transcription system effectively controls conditional gene expression in the mouse epidermis, allowing suppression and activation of specific genes with doxycycline.