Exploring Mesenchymal Stem Cells Versus Minoxidil for Androgenic Alopecia Treatment: A Detailed Animal-Based Histological and Morphometric Study

    November 2024 in “ Cells Tissues Organs ”
    Sherif A. Kamar, Khaled Hamdy, Nagwa El‐Nefiawy, H. MOHAMMED, Marwa A. Fetouh
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    TLDR Stem cells from umbilical cord blood are more effective than minoxidil for treating hair loss.
    This study compared the effectiveness of human umbilical cord blood-derived mesenchymal stem cells (HUCB-MSCs) and minoxidil in treating androgenic alopecia (AGA) using 48 adult male Wistar albino rats. The rats were divided into four groups: a control group, an AGA group, an AGA group treated with minoxidil, and an AGA group treated with HUCB-MSCs. Results showed that HUCB-MSCs significantly reversed hair and follicle damage, enhanced the anagen phase, and reduced hair loss more effectively than minoxidil. The stem cell treatment led to dense and long hair growth without side effects, suggesting it as a promising alternative for AGA treatment.
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