Bioequivalence Study of Finasteride Tablets in Human Plasma by HPLC-MS

January 2012 in “ Pharmacy Today ”

Bingren Xiang

New to Finasteride? There is a guide in the encyclopedia. Read the guide →

finasteride bioequivalence HPLC-MS plasma C18 column methanol-NH4 Acsolution Cmax AUC0-t-test Tmax Propecia

Studysummary This study concluded that two formulations of finasteride were bioequivalent based on Cmax, AUC, and Tmax data from healthy volunteers.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

View this study on en.cnki.com.cn →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 140 upvotes 2 years ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community Liquid Chromatography–Mass Spectrometry (LC-MS) VS Enzyme-Linked Immunosorbent Assay (ELISA)

5 upvotes 1 year ago

Finasteride and Nizoral shampoo with Ketoconazole are used for hair loss treatment. Liquid Chromatography–Mass Spectrometry (LC-MS) is recommended over Enzyme-Linked Immunosorbent Assay (ELISA) for more accurate DHT testing.

community Baseline bloodwork before starting Finasteride 1mg EOD – looking for comparison and discussion

2 upvotes 11 months ago

A user shared their baseline bloodwork results before starting Finasteride 1mg every other day, seeking comparison with others who have done similar tests. They are interested in any changes observed after beginning the treatment.

community Targeted Follicular Finasteride Delivery: A Low-Systemic Strategy

15 upvotes 5 months ago

A peptide-based delivery system for finasteride shows promise in reducing systemic side effects while maintaining hair growth effectiveness. Combining this with other treatments like minoxidil and RU58841 could enhance results with lower systemic absorption.

community [HELP!] TOPICAL FINASTERIDE BLOOD TEST DONE! [0.025% vs 0.015%]

8 upvotes 3 years ago

User experienced good results with topical finasteride, noting reduced DHT and increased testosterone. They plan to revert to a lower dosage after observing slight libido reduction.

community Are we underestimating systemic absorption with homemade/generic Topical Fin? (HPCH vs. PG/Ethanol formulations)

5 upvotes 7 months ago

Topical finasteride may have higher systemic absorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.

Related Research

3 / 3 results

research Bioequivalence Study of Finasteride

6 citations , December 2011 in “Drug Research”

This study concluded that Flaxin tablets and the reference formulation are bioequivalent in terms of absorption rate and extent when administered as a single 5 mg dose to healthy male volunteers.

research Bioequivalence of Two Kinds of Finasteride Tablets in Healthy Volunteers

January 2004 in “Chinese Journal of New Drugs and Clinical Remedies”

This study concluded that two different brands of finasteride tablets are bioequivalent based on their pharmacokinetic parameters and relative bioavailability.

research Determination of Finasteride in Human Plasma by LC-MS and Its Pharmacokinetics

January 2004 in “Zhongguo xin yao zazhi”

This study found that domestic finasteride tablets are bioequivalent to reference tablets, showing similar pharmacokinetic parameters and relative bioavailability.