Androgenetic Alopecia: New Insights Into the Pathogenesis and Mechanism of Hair Loss

    August 2015 in “ F1000Research ”
    Rodney Sinclair, Niloufar Torkamani, Leslie Jones
    Studysummary This study presents a new model for androgenetic alopecia progression, explaining diffuse hair loss in women through 3D reconstructions of the arrector pili muscle and its relationship with the hair follicle stem cell niche.
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    Research cited in this study 12

    1. Hair Shedding in Women: How Much Is Too Much? British Journal of Dermatology · 2015
    2. Destruction of the Arrector Pili Muscle and Fat Infiltration in Androgenic Alopecia British Journal of Dermatology · 2014
    3. Beyond Goosebumps: Does the Arrector Pili Muscle Have a Role in Hair Loss? International Journal of Trichology · 2014
    4. Miniaturized Hairs Maintain Contact With the Arrector Pili Muscle in Alopecia Areata but Not in Androgenetic Alopecia: A Model for Reversible Miniaturization and Potential for Hair Regrowth International Journal of Trichology · 2012
    5. Single Follicular Unit Transplantation Reconstructs Arrector Pili Muscle and Nerve Connections and Restores Functional Hair Follicle Piloerection The Journal of Dermatology · 2012
    6. The Ludwig Pattern of Androgenetic Alopecia Is Due to a Hierarchy of Androgen Sensitivity Within Follicular Units That Leads to Selective Miniaturization and a Reduction in the Number of Terminal Hairs Per Follicular Unit British Journal of Dermatology · 2008
    7. Follicular Miniaturization in Female Pattern Hair Loss: Clinicopathological Correlations British Journal of Dermatology · 2006
    8. Prevalence of Male and Female Pattern Hair Loss in Maryborough Journal of Investigative Dermatology Symposium Proceedings · 2005
    9. The Reliability of Horizontally Sectioned Scalp Biopsies in the Diagnosis of Chronic Diffuse Telogen Hair Loss in Women Journal of The American Academy of Dermatology · 2004
    10. Androgenetic Alopecia: Pathogenesis and Potential for Therapy Expert Reviews in Molecular Medicine · 2002
    11. Cellular And Developmental Aspects Of Androgenetic Alopecia Experimental Dermatology · 1998
    12. Fortnightly Review: Male Pattern Androgenetic Alopecia BMJ · 1998

    Related research 8

    1. Hair Follicle-Derived Mesenchymal Stem Cells Decrease Alopecia Areata Mouse Hair Loss and Reduce Inflammation Around the Hair Follicle Stem Cell Research & Therapy · 2021
    2. Role of Vitamin D in Hair Loss: A Short Review Journal of Cosmetic Dermatology · 2021
    3. Vitamin D Status in Scarring and Nonscarring Alopecia Journal of The American Academy of Dermatology · 2018
    4. The Role of Vitamin D in Non-Scarring Alopecia International Journal of Molecular Sciences · 2017
    5. Miniaturized Hairs Maintain Contact With the Arrector Pili Muscle in Alopecia Areata but Not in Androgenetic Alopecia: A Model for Reversible Miniaturization and Potential for Hair Regrowth International Journal of Trichology · 2012
    6. Abnormal Expression of VDR in the Hair Follicle of Alopecia Areata Guangdong Medical Journal · 2011
    7. Comparison of Alopecia Areata in Human and Nonhuman Mammalian Species Pathobiology · 1998
    8. Autoantibodies to Hair Follicles in C3H/HeJ Mice With Alopecia Areata-Like Hair Loss Journal of Investigative Dermatology · 1997