Development of a New Therapy for the Treatment of Chronic Ulcerative Lesions Through Allogeneic Transplantation of a Subpopulation of Mesenchymal Stem Cells Derived from Human Umbilical Cords

This study reported that a single local subcutaneous infusion of mesenchymal stromal cells from the human umbilical cord promoted wound healing, improved blood circulation, and reduced wound size in patients with chronic wounds without significant adverse effects over one year.

This study observed that using transfected human cord blood cells enhanced skin wound healing in rats by promoting angiogenesis and earlier termination of proliferation compared to untransfected cells.

This review highlighted that despite existing treatments, chronic nonhealing leg ulcers remain a significant therapeutic challenge, necessitating the development of new methods that are effective, safe, and affordable for patients.

This review suggests that the umbilical cord-derived mesenchymal stem cell secretome presents a promising approach for skin regeneration and wound healing due to its multiple therapeutic properties, highlighting its potential over traditional treatments for conditions like chronic wounds and alopecia.