TLDR 5α-reductase inhibitors like Finasteride and Dutasteride may help manage prostate cancer by blocking testosterone conversion.
The document provided an overview of the role of 5α-reductase inhibitors, specifically Finasteride and Dutasteride, in the management of prostate cancer, a common malignancy in elderly men. These inhibitors were noted for their ability to block the conversion of testosterone into dihydrotestosterone (DHT), a process implicated in the development of prostate cancer. The article discussed the biology of the prostate, the rationale behind using these inhibitors, their efficacy in preventing and treating prostate cancer, and the controversies surrounding their use.
15 citations
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December 2006 in “Clinical interventions in aging” 5 alpha-reductase inhibitors like finasteride may lower prostate cancer risk and improve cancer screening.
38 citations
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January 2005 in “PubMed” Dutasteride effectively treats enlarged prostate with manageable side effects.
20 citations
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January 2004 in “PubMed Central” 5α-reductase inhibitors like finasteride and dutasteride effectively treat BPH by reducing DHT levels.
30 citations
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August 1992 in “The Journal of Clinical Endocrinology and Metabolism” Finasteride doesn't affect hormone levels in normal men.
9 citations
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August 1992 in “The Journal of Clinical Endocrinology and Metabolism”
11 citations
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August 2020 in “Diabetes” Testosterone helps human pancreatic cells increase insulin release.
5 citations
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August 2018 in “Sexual Medicine Reviews” 5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.
52 citations
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February 2006 in “Current pharmaceutical design” 5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.
5α-reductase inhibitors effectively treat enlarged prostate and hair loss but require careful use due to possible side effects.
July 2025 in “Saudi Journal of Medicine and Public Health” 5α-reductase inhibitors effectively treat enlarged prostate and hair loss but require careful use due to possible side effects.
5α-reductase inhibitors help treat prostate enlargement and hair loss but may cause side effects, requiring careful use.
