Use of 5% Topical Minoxidil Application for Telogen Effluvium: An Open-Label Single-Arm Clinical Trial

    July 2025 in “ The Journal of Dermatology ”
    Manabu Ohyama, Ryokichi Irisawa, M Uchiyama, Miho Mori, K Aoki, Yuto Ueda, Toru Fujita
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    TLDR 5% topical minoxidil may help reduce hair loss and increase hair growth in telogen effluvium.
    This open-label, single-arm clinical trial evaluated the effectiveness of 5% topical minoxidil in treating telogen effluvium (TE) in 12 adult Japanese men and women. Over 24 weeks, participants applied the minoxidil lotion twice daily, resulting in significant improvements in hair count and condition, with 70% experiencing at least a 2-grade improvement. Both dermatologists and subjects reported high satisfaction, with 80% of participants rated as "moderately improved" or better by week 24. The treatment was generally well-tolerated, with only one adverse event directly related to minoxidil. Despite the small sample size, the study suggests that 5% topical minoxidil is a safe and effective option for improving hair growth in TE patients, though further research is needed to confirm these findings.
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