5-Alpha-Dihydrotestosterone Metabolism and Its Relationship with Middle-Phalangeal Hair and Serum Concentrations in Healthy Men

May 1986 in “ Clinics in endocrinology and metabolism ”

Vincenzo Toscano

5 Dihydrotestosterone 2D:4D ratio middle-phalangeal hair oral contraceptives prenatal testosterone exposure androgen action androgen sensitivity DHT digit ratio finger hair OCs testosterone exposure androgen effects androgen sensitivity

TLDR Certain finger length ratios and body hair patterns may predict side effects from birth control pills in women.

The document discussed the metabolism of 5-alpha-dihydrotestosterone (DHT), highlighting its relationship with middle-phalangeal hair and serum concentrations of DHT in healthy men. It referenced studies from 1992 and 1993 that found positive correlations between middle-phalangeal hair and both serum DHT levels and the ratio of DHT to total testosterone. The enzyme 5α-reductase was noted as crucial in converting testosterone to DHT, suggesting that middle-phalangeal hair might reflect 5α-reductase activity or testosterone metabolism. However, it was also mentioned that serum hormone measures might only provide a rough estimate of DHT action in hair follicles.

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Research cited in this study

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research 3 Alpha, 17 Beta-Androstanediol Glucuronide in Plasma: A Marker of Androgen Action in Idiopathic Hirsutism

179 citations , May 1982 in “The Journal of clinical investigation/The journal of clinical investigation”

High levels of 3 alpha-diol glucuronide in the blood are a marker of increased androgen action in women with excessive hair growth of unknown cause.

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community Finasteride and Eye Problems: You’re Not Going Crazy

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Finasteride can cause dry eyes and vision issues due to its impact on the meibomian glands. Users have mixed experiences, with some experiencing eye discomfort and others having no side effects.

community What treatment should I take? and is it really bad?

in Treatment 4 upvotes 1 year ago

OP is experiencing significant hair loss despite GFC and PRP treatments and has abnormal lab results. They are advised to consult a hair-focused dermatologist for further evaluation.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Be careful when switching from Finasteride to Dutasteride because for more efficacy.

in Finasteride/Dutasteride 13 upvotes 1 year ago

Switching from finasteride to dutasteride may be more effective for hair regrowth due to dutasteride's stronger enzyme inhibition, but combining both drugs could enhance results. Some users report better outcomes with dutasteride, while others recommend a gradual transition to prevent potential hair loss.

community Does finasteride/dutasteride reverse aging?

in Chat 45 upvotes 1 year ago

Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.

community DHT Itch is real. The connection between Acne and Male Pattern Baldness shows this

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The conversation discusses the link between seborrheic dermatitis, acne, and male pattern baldness, suggesting that DHT may cause both skin conditions and hair loss. Treatments mentioned include RU58841, finasteride, dutasteride, minoxidil, Nizoral shampoo, and other topical anti-androgens.

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