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research Preservation of Fertility in Transgender Men on Long-Term Testosterone Therapy: A Systematic Review of Oocyte Retrieval Outcomes During and After Exogenous Androgen Exposure

16 citations , June 2022 in “Transgender Health”

This review suggests that oocyte retrieval may be viable for transgender men on testosterone therapy, with potentially manageable effects on fertility preservation without requiring extensive hormone suspension.

research Effects of lifelong testosterone exposure on health and disease using Mendelian randomization

29 citations , October 2020 in “eLife”

This study using Mendelian randomization in UK Biobank data suggests that lifelong increased free testosterone may have mixed effects, including increased bone density and prostate cancer risk, warranting well-powered trials to address uncertainties.

research Mendelian randomization studies of testosterone exposure: A systematic review

April 2025 in “Steroids”

This review discusses the complex causal relationships between testosterone exposure and various health outcomes, but notes that the studies reviewed show substantial heterogeneity.

research Author response: Effects of lifelong testosterone exposure on health and disease using Mendelian randomization

2 citations , September 2020

This Mendelian randomization study reports that lifelong increased free testosterone in males was associated with improved bone mineral density and body composition but increased risks of prostate cancer, hypertension, and several other conditions.

research Decision letter: Effects of lifelong testosterone exposure on health and disease using Mendelian randomization

July 2020

This study using Mendelian randomization suggests lifelong increased free testosterone in males may have beneficial effects such as increased bone mineral density and decreased body fat, but also increased risks of prostate cancer and hypertension.

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Community Join

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community Testosterone and Estradiol levels on 1 mg/day dutasteride

43 upvotes 11 months ago

A 30-year-old man experienced significant hair regrowth and improved libido after using finasteride and dutasteride for androgenetic alopecia, with no adverse effects. He plans to reduce dutasteride dosage when trying to conceive and has been using topical minoxidil since 2015.

community Testosterone and hair loss seeming irrelevance

82 upvotes 3 years ago

The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

community My Testosterone results before and after Finasteride

147 upvotes 5 years ago

Finasteride significantly increased testosterone levels for the user, with no major side effects except watery semen, which was resolved with zinc supplements. The user's hairline stopped receding and slightly improved.

community Japan Uses Low Dose Dutasteride (0.1mg). Minimal exposure and hair growth success.

273 upvotes 6 months ago

Low-dose dutasteride (0.1 mg) is effective for hair growth, potentially more so than finasteride, with fewer side effects. East Asians may respond well to these treatments due to hair characteristics.

community DHT levels went up after 6 months of finasteride usage.

22 upvotes 2 weeks ago

Finasteride's effectiveness may be reduced due to heat exposure, affecting DHT levels. Testing methods and medication storage conditions are likely factors in the unchanged DHT levels.

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Learn

3 / 801 results

learn Clascoterone

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

learn Dutasteride

Heavy duty finasteride that comes with higher risks

learn Bicalutamide

Could bicalutamide help trans women regrow hair lost to testosterone? No study has tested bicalutamide for hair regrowth in trans women. In cisgender women the only randomized trial found it added nothing to minoxidil, and it is an off-label prescription drug that requires liver monitoring.

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Clinics

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