Single-Cell Analysis of Basal Cell Carcinoma Reveals Heat Shock Proteins Promote Tumor Growth in Response to WNT5A-Mediated Inflammatory Signals

October 2021 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Christian F. Guerrero‐Juarez, Gun Ho Lee, Yingzi Liu, Shuxiong Wang, Yutong Sha, Rachel Y. Chow, Tuyen T. L. Nguyen, Sumaira Z. Aasi, Matthew Karikomi, Michael L. Drummond, Qing Nie, Kavita Y. Sarin, Scott X. Atwood

basal cell carcinoma heat shock proteins WNT5A fibroblasts STAT1 TGF-β HSP70 Hedgehog signaling BCC HSPs

Studysummary This study found that targeting HSP70 can suppress basal cell carcinoma growth, underscoring the importance of tumor microenvironment interactions in cancer progression.

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