MiR-29 Is an Important Driver of Aging-Related Phenotypes

December 2022 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Vijay Swahari, Ayumi Nakamura, Émilie Hollville, Yu‐Han Hung, Matt Kanke, C. Lisa Kurtz, Xurde M. Caravia, Shirley He, Janakiraman Krishnamurthy, Sahil Kapoor, V. S. Prasad, Cornelius Flowers, Matt Beck, Jeanette Baran-Gale, Norman E. Sharpless, Carlos López-Otı́n, Praveen Sethupathy, Mohanish Deshmukh

miR-29 alopecia senescence extracellular matrix fatty acid metabolism inflammation-related genes

Studysummary In this study, overexpression of miR-29 in mice led to aging-related phenotypes and early lethality, demonstrating its significant role in driving aging processes.

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