1363 Hair follicle growth and pigmentation during ageing
May 2018
in “Journal of Investigative Dermatology”
TLDR The research found that a specific skin cell type not only triggers hair growth but also controls hair color, and that aging can lead to hair loss and color changes.
The document discusses the role of the dermal papilla (DP) in hair follicle growth and pigmentation, particularly during aging. The researchers developed new genetic tools to isolate and target the DP, melanocyte, and stem cell compartments within the hair follicle. They discovered that the DP not only induces hair growth but also strongly regulates hair follicle pigmentation. This was demonstrated by conditionally knocking down genes in the DP compartment, which resulted in a pigment switch in the pelage of conditional knockout (CKO) mice. Additionally, the study explored the common consequences of skin aging, such as hair loss and pigmentation disorders, by using novel senescence biomarkers to identify senescent cells within different compartments of mouse and human skin. By inducing senescence within different hair follicle compartments in vivo, they aimed to establish causality for hair loss and de-pigmentation during aging. The ultimate goal of this research is to identify mechanisms of hair loss and de-pigmentation to aid in the development of new treatments.
View this study on jidonline.org →
Related
research Activation of β-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth
Activating β-catenin in certain skin cells speeds up hair growth in mice.
research 693 Dermal papilla-derived Wnt ligands are required for adult hair follicle growth
Wnt ligands, produced by dermal papilla cells, are essential for adult hair growth and regeneration.
research Melanocyte stem cells: a melanocyte reservoir in hair follicles for hair and skin pigmentation
Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.
research Melanocyte Subpopulation Turnover During the Human Hair Cycle: An Immunohistochemical Study
Melanocyte activity in hair follicles is linked to the hair growth cycle, being active in growth phases and inactive in rest phases.
research An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation.
Estrogen affects hair growth and skin cell multiplication.