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community Minimizing systemic DHT reduction with topicals

5 upvotes 1 month ago

The conversation discusses minimizing systemic DHT reduction using topical treatments for hair loss, specifically mentioning Minoxidil, Finasteride, and a proprietary carrier for DUT by XYON Health. The focus is on finding effective DHT blockers with minimal systemic absorption.

community Are all of these hair treatment companies the same?

in Treatment 1 upvotes 1 year ago

The user has been using topical finasteride and minoxidil since 2021 and is exploring other hair treatment companies like Xyon and Happy Head due to dissatisfaction with the current product's smell. They question the authenticity of consultations from these companies, suspecting they might be automated.

community Discontinuing oral finasteride after 7 years and switching topical

in Progress Pictures 771 upvotes 1 year ago

A user stopped oral finasteride after 7 years due to decreased libido and switched to topical finasteride and minoxidil. Others shared similar experiences and discussed alternatives like dutasteride and topical treatments.

community where to buy 0.025 topical finasteride in liposomal gel form in europe?

6 upvotes 2 years ago

The conversation is about finding a place to buy 0.025% topical finasteride in liposomal gel form in Europe. The user previously mixed their own with stemoxydine but stopped due to an oily scalp.

community A Nuanced Look at Microdosing Topical Finasteride

86 upvotes 2 years ago

The conversation discusses using a low dose of topical finasteride to achieve hair benefits with minimal systemic exposure. Users share experiences and opinions on dosing, systemic buildup, and side effects of both topical and oral finasteride.

View more "xyon topical finasteride" in community →

Research

5 / 1000+ results

Single and Repeated Dose of Finasteride Topical Solution in Subjects with Androgenetic Alopecia: A Pharmacokinetic and Pharmacodynamic Study

research Single and repeated dose of finasteride topical solution in subjects with androgenetic alopecia: A pharmacokinetic and pharmacodynamic study

February 2013 in “Journal of The American Academy of Dermatology”

Finasteride solution helps treat hair loss.

research Compounded topical finasteride-related AEs

May 2025 in “Reactions Weekly”

research Topical Finasteride: A Comprehensive Review of Androgenetic Alopecia Management for Men and Women

September 2023 in “Cureus”

This study reviewed early research on topical finasteride for androgenetic alopecia, finding it appears safe and promising, though further investigation is needed to determine optimal dosing, frequency, and potential applications for other types of alopecia.

research Tell me the uses, effectiveness, and adverse effects of topical finasteride in the treatment of androgenetic alopecia.

May 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

Topical finasteride effectively treats hair loss with fewer side effects than the oral form.

research 1048 Treatment of nodulocystic acne with once weekly finasteride: A pilot study

April 2018 in “Journal of Investigative Dermatology”

This study suggests that weekly oral finasteride may be a promising alternative to isotretinoin for treating nodulocystic acne, showing substantial improvements with lower incidence of sexual dysfunction.

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Learn

9 / 801 results

learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. Topical finasteride offers localized treatment with fewer systemic side effects than oral finasteride.
Are there really risks with topical finasteride? Reports on topical finasteride describe scalp irritation and dermatitis as the effects specific to it, and blood levels lower than the oral drug; whether systemic side effects are genuinely rarer has not been measured in a trial powered to answer it. Both forms are prescription-only and contraindicated around pregnancy.

learn RU58841

a potent but unapproved and potentially problematic topical anti-androgen

learn Nanoxidil

learn Fluridil

a topical anti-androgen with less systemic involvement

learn Capixyl

learn Clascoterone

a novel topical treatment that inhibits DHT on androgen receptors

learn Bicalutamide

Is topical bicalutamide a safer alternative to finasteride? There is no published human trial of topical bicalutamide for hair loss, and no licensed topical product exists, so it cannot be called safer than finasteride — or shown to work at all. Oral finasteride has decades of trial data with a documented side-effect profile, and topical finasteride has a phase III trial behind it.

learn KX-826

Kintor Pharmaceutical: KX-826, a New Name in Hair Loss Research KX-826 (pyrilutamide) is an experimental topical androgen receptor blocker from Kintor Pharmaceutical. It is not approved as a medicine anywhere; the company reports that its China Phase III trial met its primary endpoint at 24 weeks, but the trial data has been released through corporate announcements rather than peer-reviewed journals and long-term safety is unknown.

learn Pyrilutamide

Is pyrilutamide a safer alternative to oral antiandrogens like finasteride? Pyrilutamide may be a safer topical alternative to oral antiandrogens like finasteride.

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