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    Glossary Winlevi

    Winlevi, or clascoterone, is a topical medication approved for the treatment of acne and is being investigated for its potential use in addressing androgenetic alopecia, a common form of hair loss. It functions as an androgen receptor inhibitor, which means it can block the effects of androgens like dihydrotestosterone (DHT) that contribute to hair follicle miniaturization. Its relevance in hair biology lies in its ability to target the hormonal pathways involved in hair loss, offering a novel approach to treatment without the systemic side effects associated with oral medications. Key distinguishing characteristics include its topical application and its mechanism of action that specifically addresses androgen-related hair loss.

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      learn Clascoterone

      a novel topical treatment that inhibits DHT on androgen receptors

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      research Clascoterone: First Approval

      27 citations , October 2020 in “Drugs”
      This article reviews the development milestones of clascoterone up to its first approval for treating acne vulgaris, reporting no new clinical results for androgenetic alopecia.
      Journal of Pigmentary Disorders

      research Journal of Pigmentary Disorders

      3 citations , March 2019 in “Journal of Pigmentary Disorders”
      This presentation highlighted future directions in acne care, emphasizing the roles of topical and oral antibiotics, as well as skin microbiome studies. It also described how clascoterone targets androgen receptors in hair follicles and sebaceous glands to reduce sebum production.