57 citations
,
October 1996 in “Dermatologic clinics”
This study found that using hyaluronic acid microneedles to deliver minoxidil significantly reduced hair loss in chemotherapy-induced alopecia mice, with only 10% of the dose used in topical applications.
This study found that IL-1 alpha inhibits the growth of cultured human hairfollicles and hair fibers, suggesting a potential role in inflammatory hair loss conditions like alopecia areata.
27 citations
,
September 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”
This study found that relatively low concentrations of 1,25(OH)2D3 stimulated human hairfollicle and fiber growth, while higher concentrations inhibited growth in a whole-organ culture system.
31 citations
,
January 1993 in “Skin Pharmacology and Physiology”
This study suggests that potassium channel openers, such as minoxidil, may stimulate hair growth by retarding the loss of proliferative activity in mouse hairfollicles.
A new stem cell method for culturing hairfollicles is being developed as an alternative to Minoxidil, finasteride, and RU58841. There are concerns about its cost and accessibility despite plans for commercialization.
Cannabis and THC may have mixed effects on hair, with some studies suggesting potential negative impacts on hair growth in isolated hairfollicles, but these results are hard to apply to living humans. Treatments like minoxidil and finasteride are commonly used for hair loss, and the effects of cannabis might be neutral or vary based on individual factors.
Vitamin D may counteract DHT and help with hair growth, as seen in mice and human haircultures. Some users discuss using Vitamin D, magnesium, and other supplements for hair health, while others humorously note the success in mice.
Tretinoin can cause non-telogen hair loss in some men by inducing catagen-like changes in hairfollicles and through retinoid toxicity, especially when used with minoxidil. Some users report hair loss even when using retinoids on the face, while others experience benefits when combined with treatments like finasteride and minoxidil.
Hairfollicle cloning is claimed to be possible but not widely available due to potential safety issues, such as cancer risks. Current treatments like finasteride and dutasteride are not effective for everyone, and there is frustration over limited access to these medications.