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research Efficacy and safety of autologous cell-based therapies for atrophic acne scar treatment: an updated systematic review and meta-analysis with in-depth methodological and clinical insights

March 2026 in “Frontiers in Cell and Developmental Biology”

This meta-analysis found that autologous cell-based therapies, especially stromal vascular fraction, significantly improved atrophic acne scars over control treatments, enhancing both clinical and patient-reported outcomes.

research Hypoxic Preconditioning Prevents Oxidative Stress-Induced Cell Death in Human Hair Follicle Stem Cells.

July 2024 in “PubMed”

In this study, researchers explored how hypoxic preconditioning affects the survival and oxidative stress resilience of nestin-expressing hair follicle stem cells and SH-SY5Y neuroblastoma cells, focusing on changes in gene expression for HIF1α, BDNF, and VEGF.

research Protective effects of human umbilical cord blood‑derived mesenchymal stem cells against dexamethasone‑induced apoptotic cell death in hair follicles

12 citations , December 2019 in “International Journal of Molecular Medicine”

This study found that human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) significantly prevented hair loss induced by dexamethasone in a mouse model and enhanced cell proliferation in human hair follicle cells, suggesting a protective effect against stress-related hair loss.

research 42276 Long-Term Safety of Ixekizumab Treatment in Adult Patients with Psoriasis, Psoriatic Arthritis, or Axial Spondyloarthritis: A Post-hoc Analysis of End-Of-Study Program Data Relating to Major Adverse Cardiovascular Events

September 2023 in “Journal of the American Academy of Dermatology”

This study found that the incidence of major adverse cardiovascular events in patients with psoriasis, psoriatic arthritis, and axial spondyloarthritis who received Ixekizumab was low and stable over 3 to 5 years across 25 clinical trials.

research Cutaneous Manifestations in COVID-19: Report on 31 Cases from Five Countries

7 citations , January 2021 in “Biology”

This study documented a variety of skin lesions in COVID-19 patients, indicating that skin rashes might be an early or sole symptom of the disease.

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Community Join

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community Microneedling must reach the stem cells in the upper hair shaft

82 upvotes 4 years ago

Microneedling should target depths of 0.5mm to 1.5mm for hair loss, with weekly sessions at 1mm recommended. Combining microneedling with Minoxidil is common for improved results.

community Has anyone tried Matrixyl 3000 topically for hair growth?

in Research/Science 4 upvotes 3 years ago

Matrixyl 3000 is discussed as a potential topical treatment for hair growth, but concerns are raised about excess collagen production being a consequence of hair loss. The conversation suggests that androgen-induced miniaturization leads to hair follicle death and skin fibrosis.

community Dutasteride takes 1-3 months to work in the scalp. Not weeks. Be careful.

in Finasteride/Dutasteride 41 upvotes 2 years ago

Dutasteride takes 1-3 months to affect scalp DHT levels, not just a week. The prostate absorbs Dutasteride faster than the scalp due to different vascular networks and enzyme densities.

community Comprehensive Microneedling Guide

292 upvotes 4 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community Someone please offer reassurance

in Minoxidil 3 upvotes 1 month ago

A 19-year-old male is experiencing hair shedding while using oral minoxidil, ketoconazole, dermastamping, and saw palmetto, and is considering switching to finasteride for better results. Users suggest that saw palmetto may not be effective and recommend finasteride instead, while also discussing other treatments like rosemary oil, peppermint oil, and pumpkin seed oil.

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Learn

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learn Vascular Endothelial Growth Factor

What is Vascular Endothelial Growth Factor (VEGF), and how does it support hair growth in alopecia? In mice, VEGF supports hair growth by increasing blood vessels around follicles. There is no direct evidence that raising VEGF treats hair loss in people.
Can products that stimulate Vascular Endothelial Growth Factor (VEGF) improve blood flow to hair follicles? Unproven. Raising VEGF increases vessels around follicles in mice and minoxidil raises VEGF in cultured cells, but no study shows VEGF-marketed products improve scalp blood flow or hair loss in people.
Is Vascular Endothelial Growth Factor (VEGF) available as a topical treatment, or is it only stimulated indirectly? VEGF is not available as a topical treatment for hair loss.
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Clinics

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Hair Loss Treatments
VIVAA-Vein Vascular Primary Care & Aesthetic AssociatesIssaquah, WA · US

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