Hypoxic Preconditioning Prevents Oxidative Stress-Induced Cell Death in Human Hair Follicle Stem Cells

    July 2024 in “ PubMed ”
    Mohammad Saied Salehi, Fatemeh Changiz Khani, Sabiha M. Ansari, Mohammad Javad Mokhtari, Mahintaj Dara, Mahnaz Bayat, Etrat Hooshmandi, Nahid Ashjazadeh, Afshin Borhani‐Haghighi, Gökhan Ünal, Sareh Pandamooz
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    TLDR Hypoxic preconditioning helps human hair follicle stem cells survive oxidative stress.
    The study explored the effects of hypoxic preconditioning on human hair follicle stem cells (hHFSCs) and SH-SY5Y neuroblastoma cells, revealing that hHFSCs showed remarkable resilience to hypoxic conditions, with no cell death after 3 days, unlike SH-SY5Y cells. Hypoxic preconditioning improved hHFSCs' survival under oxidative stress, particularly at 1200 micromolar H2O2, and led to significant gene expression changes, including downregulation of HIF1α mRNA and increased VEGF transcripts. These findings suggest that hypoxic preconditioning could enhance the survival and therapeutic efficacy of hHFSCs in cell therapy applications, especially for central nervous system conditions, although further research is needed to understand the mechanisms involved.
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