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GlossaryTransient Receptor Potential Vanilloid 1 (Vanilloid Receptor 1)

protein channel that detects heat, acidity, and capsaicin

Transient Receptor Potential Vanilloid 1 (TRPV1), also known as the Capsaicin Receptor, is a protein found on the surface of certain cells, including sensory neurons. It acts as an ion channel that opens in response to heat, acidic conditions, and capsaicin (the compound that makes chili peppers hot), playing a crucial role in the sensation of pain and temperature.

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research A Hot New Twist to Hair Biology: The Role of TRPV1 in Human Hair Growth Control

174 citations, April 2005 in “The American journal of pathology (Print)”

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

research Activation of Transient Receptor Potential Vanilloid-3 Inhibits Human Hair Growth

105 citations, May 2011 in “The journal of investigative dermatology/Journal of investigative dermatology”

Activating TRPV3 stops human hair growth.

Pharmacological Activation of Thermo-Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath

research Pharmacological Activation of Thermo-Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath

12 citations, May 2019 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics”

Activating TRPV3 channels stops hair growth by killing hair follicle cells.

Human Epithelial Stem Cell Survival Within Their Niche Requires Tonic Cannabinoid Receptor 1 Signaling—Lessons From the Hair Follicle

research Human Epithelial Stem Cell Survival Within Their Niche Requires Tonic Cannabinoid Receptor 1 Signaling—Lessons From the Hair Follicle

14 citations, February 2021 in “Experimental Dermatology”

Cannabinoid receptor-1 signaling is essential for the survival and growth of human hair follicle stem cells.

research Red Ginseng Extract Promotes Hair Growth in Cultured Human Hair Follicles

49 citations, November 2014 in “Journal of Medicinal Food”

Red Ginseng Extract may help human hair grow by activating growth pathways and blocking negative effects of certain hormones.

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community Natural Remedies: Polyphenols and Hair Loss

19 upvotes 5 years ago

Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.