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    Did you mean TYK2 Inhibitor?
    Glossary TYK2 Inhibitor

    blocks enzyme activity to reduce inflammation in autoimmune diseases

    A TYK2 inhibitor is a type of medication that blocks the activity of the TYK2 enzyme, which is involved in the immune system's signaling pathways. By inhibiting this enzyme, these drugs can help reduce inflammation and are being researched for treating autoimmune diseases like psoriasis and alopecia areata.

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    Research 10 of 229

    1. JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician Journal of Family Medicine and Primary Care · 2024 · 6 citations
    2. 544 Alopecia areata lesions show significant changes in immune and keratin biomarkers that correlate with clinical improvement with oral Janus kinase inhibitors PF-06651600 (JAK3) and PF-06700841 (TYK2/JAK1) Journal of Investigative Dermatology · 2019 · 5 citations
    3. 265 Modulation of disease-central cytokine pathways with TAK-279, a highly selective oral tyrosine kinase 2 (TYK2) inhibitor, defines clinical response in patients with psoriasis Journal of Investigative Dermatology · 2024 · 1 citations
    4. Innovative Therapeutic Strategies in TYK2-Targeted Treatments: From Cancer to Autoimmune Disorders ACS Medicinal Chemistry Letters · 2024 · 1 citations
    5. A review of Janus kinase inhibitor use in scarring alopecia JAAD reviews. · 2025 · 4 citations
    6. TYK2 Inhibition with Deucravacitinib Improves Clinical Outcomes and Resolves Interferon-Driven Inflammation in Lichen Planopilaris 2026
    7. Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, in patients with alopecia areata: efficacy and safety results of a phase II, multicenter, randomized, double-blinded, placebo-controlled trial British Journal of Dermatology · 2026
    8. Rapid hair regrowth in an alopecia universalis patient with deucravacitinib: A case report SAGE open medical case reports · 2023 · 1 citations
    9. Modern Therapies for Discoid Lupus Erythematosus: A Narrative Review Dermatology and Therapy · 2026
    10. Review of Promising Off-Label Use of Deucravacitinib International Journal of Molecular Sciences · 2025
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