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    Did you mean TYK2 Inhibitor?
    Glossary TYK2 Inhibitor

    blocks enzyme activity to reduce inflammation in autoimmune diseases

    A TYK2 inhibitor is a type of medication that blocks the activity of the TYK2 enzyme, which is involved in the immune system's signaling pathways. By inhibiting this enzyme, these drugs can help reduce inflammation and are being researched for treating autoimmune diseases like psoriasis and alopecia areata.

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    Research 30 of 229

    1. JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician Journal of Family Medicine and Primary Care · 2024 · 6 citations
    2. 544 Alopecia areata lesions show significant changes in immune and keratin biomarkers that correlate with clinical improvement with oral Janus kinase inhibitors PF-06651600 (JAK3) and PF-06700841 (TYK2/JAK1) Journal of Investigative Dermatology · 2019 · 5 citations
    3. 265 Modulation of disease-central cytokine pathways with TAK-279, a highly selective oral tyrosine kinase 2 (TYK2) inhibitor, defines clinical response in patients with psoriasis Journal of Investigative Dermatology · 2024 · 1 citations
    4. Innovative Therapeutic Strategies in TYK2-Targeted Treatments: From Cancer to Autoimmune Disorders ACS Medicinal Chemistry Letters · 2024 · 1 citations
    5. A review of Janus kinase inhibitor use in scarring alopecia JAAD reviews. · 2025 · 4 citations
    6. TYK2 Inhibition with Deucravacitinib Improves Clinical Outcomes and Resolves Interferon-Driven Inflammation in Lichen Planopilaris 2026
    7. Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, in patients with alopecia areata: efficacy and safety results of a phase II, multicenter, randomized, double-blinded, placebo-controlled trial British Journal of Dermatology · 2026
    8. Rapid hair regrowth in an alopecia universalis patient with deucravacitinib: A case report SAGE open medical case reports · 2023 · 1 citations
    9. Modern Therapies for Discoid Lupus Erythematosus: A Narrative Review Dermatology and Therapy · 2026
    10. Review of Promising Off-Label Use of Deucravacitinib International Journal of Molecular Sciences · 2025
    11. Deucravacitinib in dermatology: current indication and existing off-label data Drugs in Context · 2026
    12. JAK Family Expression and Therapeutic Implications in Primary Cicatricial Alopecias International Journal of Dermatology · 2025
    13. Complete hair regrowth in a patient with severe alopecia areata treated with deucravacitinib Clinical and Experimental Dermatology · 2025 · 1 citations
    14. 27 Preclinical ex vivo and in vivo evidence supporting selective inhibition of tyrosine kinase 2-dependent, IL-12-mediated signaling as a novel pharmacological strategy for alopecia areata management 2023
    15. 700 Tyrosine kinase 2 inhibition rescues hair follicles from IL-12–mediated immune privilege collapse and reverses the induction of human alopecia areata in a humanized mouse model Journal of Investigative Dermatology · 2022
    16. Wiederbehaarung bei einem Patienten mit Alopecia universalis und Psoriasis vulgaris unter Deucravacitinib‐Therapie JDDG Journal der Deutschen Dermatologischen Gesellschaft · 2025
    17. 802 Molecular effect of brepocitinib in hidradenitis suppurativa (HS) Journal of Investigative Dermatology · 2024
    18. Discoid lupus erythematosus successfully treated with deucravacitinib JAAD Case Reports · 2024 · 13 citations
    19. 290 Brepocitinib improves cicatricial alopecia and downregulates key T-helper biomarkers Journal of Investigative Dermatology · 2024
    20. 061 Selective inhibition of tyrosine kinase 2 prevents and restores interleukin-12-induced hair follicle immune privilege collapse: a novel approach to alopecia areata therapy? Journal of Investigative Dermatology · 2021
    21. Hair regrowth in a patient with alopecia universalis and psoriasis vulgaris during deucravacitinib therapy JDDG Journal der Deutschen Dermatologischen Gesellschaft · 2024
    22. 014 Tyrosine Kinase 2 Inhibition Ameliorates the Phenotype of Lesional Alopecia Areata Scalp Skin Ex Vivo, and Reverses the Induction of Human Alopecia Areata in a Humanized Mouse Model 2022
    23. A phase 2a trial of brepocitinib for cicatricial alopecia Journal of the American Academy of Dermatology · 2024 · 17 citations
    24. Janus Kinase inhibitors in dermatology: a review Portuguese Journal of Dermatology and Venereology · 2023 · 1 citations
    25. Safety of Janus Kinase inhibitors in Patients with Alopecia Areata: A Systematic Review Clinical drug investigation · 2023 · 3 citations
    26. Small Molecule Inhibitors and Inflammatory Skin Diseases Suez Canal University Medical Journal · 2018
    27. The Role of Janus Kinase Inhibitors in Dermatology Eduvest - Journal Of Universal Studies · 2026
    28. Janus kinase (JAK) inhibitors for the treatment of skin and hair disorders: a review of literature Journal of Dermatological Treatment · 2016 · 40 citations
    29. Efficacy and safety of different JAK inhibitors in the treatment of alopecia areata: a network meta-analysis Frontiers in immunology · 2023 · 7 citations
    30. Janus kinase inhibitors for alopecia areata: a review of clinical data Frontiers in Immunology · 2025 · 4 citations