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    GlossaryTherapeutic Target (treatment target)

    specific molecule or pathway involved in disease for treatment

    A therapeutic target, also known as a treatment target, is a specific molecule or pathway in the body that is identified as playing a key role in a disease process. By focusing on this target, researchers and doctors can develop treatments that specifically interfere with the disease mechanism, potentially leading to more effective and precise therapies. For example, in the context of alopecia, a therapeutic target might be a particular protein or gene involved in hair follicle health and growth.

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      a nonsteroidal anti-androgen, most commonly used orally for women

      learn PP405

      mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

      learn SCUBE3

      a signaling molecule from dermal papilla cells being actively researched

      learn Rapamycin

      mTOR regulator and immunosuppressant used more recently for anti-aging and hair regrowth

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      community BREEZULA COVID UPDATE: Filing for Special Protocol Assessment with FDA

      in Research/Science  62 upvotes 4 years ago
      The conversation discusses the progress of Clascoterone (Breezula) for hair loss treatment, noting that COVID-19 delayed female trials by three months but Phase III trials for males are proceeding with a Special Protocol Assessment filed with the FDA. Users express hope for Breezula as an alternative to existing treatments like finasteride and minoxidil, despite concerns about its potential high cost.

      community Verteporfin and Microneedling

      in Treatments 3 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community The Big Fat Layer II

      in Research/Science  26 upvotes 3 years ago
      Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.