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GlossaryTransglutaminase 3

enzyme crucial for skin and hair protein cross-linking

Transglutaminase 3 (TGM3) is an enzyme that plays a crucial role in the formation and maintenance of the outer layer of the skin and hair follicles. It helps in the cross-linking of proteins, which strengthens the structural integrity of these tissues. Deficiencies or malfunctions in TGM3 can lead to skin disorders and hair loss conditions.

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research Transglutaminase 5 Expression in Human Hair Follicle

28 citations , August 2005 in “Journal of Investigative Dermatology”

TG5 helps maintain hair follicle health, while TG3 aids in hair shaft development.

research Peer Review of Human Hair Shaft Proteomic Profiling: Individual Differences, Site Specificity, and Cuticle Analysis

August 2014

The research found that people's hair proteins vary, especially by ethnicity and body part, which could help identify individuals in forensic science.

research Human Hair Shaft Proteomic Profiling: Individual Differences, Site Specificity, and Cuticle Analysis

August 2014

The research found that people's hair proteins vary by individual and body part, with some differences between ethnic groups, which could help in forensics.

research Transglutaminase 3: The Involvement in Epithelial Differentiation and Cancer

22 citations , August 2020 in “Cells”

TGM3 is important for skin and hair structure and may help diagnose cancer.

research Transglutaminase Activity Is Conserved in Stratified Epithelia and Skin Appendages of Mammals and Birds

8 citations , January 2023 in “International journal of molecular sciences”

Transglutaminase activity is important for skin and is found in both mammals and birds.

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