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    Glossary Transglutaminase 3

    enzyme crucial for skin and hair protein cross-linking

    Transglutaminase 3 (TGM3) is an enzyme that plays a crucial role in the formation and maintenance of the outer layer of the skin and hair follicles. It helps in the cross-linking of proteins, which strengthens the structural integrity of these tissues. Deficiencies or malfunctions in TGM3 can lead to skin disorders and hair loss conditions.

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      research Human epidermal transglutaminase. Preparation and properties.

      138 citations , December 1976 in “Journal of Biological Chemistry”
      This study purified a transglutaminase enzyme from human epidermis that requires calcium or strontium for activity and forms cross-linked polymers, but its detailed activation mechanism remains unclear.
      The Proximal Promoter of the Human Transglutaminase 3 Gene

      research The Proximal Promoter of the Human Transglutaminase 3 Gene

      105 citations , February 1996 in “Journal of biological chemistry/˜The œJournal of biological chemistry”
      In this study, sequences upstream of the TGM3 gene were found to regulate epithelial-specific gene expression in keratinocytes, suggesting potential applications in gene therapy.

      research Transglutaminase from Hair Follicle of Guinea Pig

      103 citations , February 1972 in “Proceedings of the National Academy of Sciences”
      This study found that a unique transglutaminase in guinea pig hair-follicles, distinct from liver transglutaminase, likely plays a role in forming protein cross-links via ε(γ-glutamyl)lysine bonds.

      research Kinetic Studies with Transglutaminases

      91 citations , May 1972 in “Journal of Biological Chemistry”
      This research found that the transfer reaction catalyzed by human plasma and guinea pig hair follicle transglutaminases aligns with a ping-pong mechanism involving peptide-bound glutamine.