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research SUN-049 Male Pattern Baldness and Waist-Hip Ratio as Markers of Arterial Stiffness in Transgender Men Undergoing Long-Term Testosterone Therapy

April 2020 in “Journal of the Endocrine Society”

This study found that among transgender men undergoing long-term testosterone therapy, a severe pattern of androgenetic alopecia may indicate increased arterial stiffness, as measured by higher intima-media thickness of the carotid artery.

research Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.

26 citations , June 2003 in “PubMed”

In this study, severe hair loss occurred in PKC epsilon transgenic mice treated with DFMO during skin tumor prevention, highlighting a link between polyamine biosynthesis, hair follicle maintenance, and metastasis suppression.

research Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature

15 citations , June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study identifies KLK14 as a significant factor contributing to hair defects and skin inflammation in a mouse model of Netherton syndrome.

research Transgenic Immortalization of Human Dermal Fibroblasts Mediated Through the MicroRNA/SIRT1 Pathway

7 citations , December 2021 in “In Vivo”

In this study, researchers found that hTERT/SV40 immortalization of human dermal fibroblasts up-regulates skin cell markers and highlights the SIRT1 and miR-93 pathways' roles in maintaining fibroblast proliferation, potentially benefiting developments in the cosmetic industry.

research Medical dermatologic conditions in transgender women

12 citations , October 2018 in “International Journal of Women's Dermatology”

This review discusses lesser-known concerns in transgender dermatology, including neovaginal issues, neoplastic and autoimmune conditions, and the effects of unapproved injectable substances, but reports no new clinical findings.

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Learn

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learn Follistatin

Is follistatin safe for use in women or transgender individuals undergoing hormone therapy? No study has tested follistatin in women or transgender people on hormone therapy, and it has no approved human use or established dose; a 2023 study in 72 adolescents with PCOS found that the body's own follistatin rose on estrogen-containing contraceptives alongside less favourable metabolic markers, a correlation that does not show follistatin caused them. The published evidence does not support using it in this group.

learn Dutasteride

5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride

learn Estradiol

Why is Estradiol used to treat hair loss in women and transgender people undergoing hormone therapy? Estradiol is used within supervised hormone therapy and may slow hormone-related hair loss in some women and trans women, but the evidence is limited and it carries serious whole-body risks.

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Community Join

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community Effect of dutasteride 0.5 mg/d in men who don't respond to finasteride (study)

in Research/Science 31 upvotes 1 year ago

Dutasteride improved hair density and thickness in men who didn't respond to finasteride, with some experiencing transient sexual dysfunction. Users discussed switching from finasteride to dutasteride, noting initial shedding but eventual hair improvement.

community There’s nothing better on the horizon [RANT]

22 upvotes 1 month ago

There is skepticism about new hair loss treatments, with the belief that current options like minoxidil, finasteride, and hair transplants are the best available. Concerns are raised about the systemic side effects of androgen-related treatments, even those marketed as topical, and doubts about the effectiveness of emerging treatments like clascoterone.

community KX-826 0.5% BID ~2 months monotherapy(?) results

8 upvotes 1 month ago

The user reported positive results using KX-826 0.5% twice daily for hair loss, noting progress in the temple area with no systemic side effects. They avoided finasteride and minoxidil due to concerns about side effects and inconvenience, respectively, and used ketoconazole shampoo for seborrheic dermatitis.

community Jeff Vincent and his stealth drug growth stimulant is on track for Q1 2027

89 upvotes 1 month ago

A new hair growth drug claims to reverse severe hair loss without using minoxidil, finasteride, or hormone-altering drugs, but many are skeptical due to lack of evidence and concerns about misleading claims. The drug is expected to be released in early 2027, but its legitimacy is questioned.

community Amplifica: Hope or Cope? A Review of Their Pipeline

9 upvotes 1 month ago

Amplifica's AMP-303 showed a modest increase in hair growth, but results were inconsistent and potentially misleading. Hyaluronic acid and osteopontin are being explored for hair growth, with varying effects on different hair types and conditions.

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