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research Evaluation of methotrexate-loaded surfactants, ceramides and cholesterol-based lamellar phases as a topical treatment for psoriasis

2 citations , February 2022 in “Journal of Pharmacy and Pharmacology”

In this study, two methotrexate-loaded liquid crystal formulations for topical application showed immunomodulatory effects and induced skin changes in mice with imiquimod-induced psoriasis.

Niosomes as a Promising Carrier for Topical Drug Delivery

research Niosomes as a propitious carrier for topical drug delivery

72 citations , December 2012 in “Expert Opinion on Drug Delivery”

This review discusses niosomes' increasing popularity in dermatology for topical drug delivery due to their ability to enhance drug penetration, provide sustained release, and carry various drugs, while reporting no new clinical findings.

research Suppression of FGF5 and FGF18 Expression by Cholesterol-Modified siRNAs Promotes Hair Growth in Mice

9 citations , July 2021 in “Frontiers in Pharmacology”

This study found that intradermal injection of cholesterol-modified siRNA targeting FGF5 or FGF18, or topical application of FGF18-targeted siRNA, effectively influenced hair follicle cycles in mice, suggesting potential benefits for alopecia management.

The 'Bald' Phenotype (Androgenetic Alopecia) Is Caused by the High Glycemic, High Cholesterol, and Low Mineral 'Western Diet'

research The ‘bald’ phenotype (androgenetic alopecia) is caused by the high glycaemic, high cholesterol and low mineral ‘western diet’

7 citations , June 2021 in “Trends in Food Science and Technology”

This commentary reviews potential dietary and mineral influences on androgenetic alopecia and suggests considering a diet low in cholesterol and glycaemic index with improved glucose control and magnesium fortification, without new clinical results.

research Development and Characterization of Dutasteride Bearing Liposomal Systems for Topical Use

4 citations , May 2011 in “Current Drug Discovery Technologies”

This study found that a dutasteride-loaded liposomal system significantly increased skin permeability and drug deposition in mouse skin compared to other formulations, suggesting improved localized treatment potential for androgenetic alopecia.

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Community Join

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community Anti-Androgens causing hairline to recede?

in Research/Science 5 upvotes 2 years ago

Anti-androgens like Finasteride, Dutasteride, Metformin, and Topical Spironolactone cause hairline recession and increased cholesterol levels. The hairline recovers after stopping the drugs.

community Why isnt topical fin talked about more?

in Chat 44 upvotes 1 year ago

Topical finasteride is less popular due to inconvenience, cost, and availability, while oral finasteride is favored for ease and safety. Some users experience side effects with topical use, but find it effective with minoxidil, though opinions on its efficacy vary.

community M27 Fin/Min (topical) was fun while it lasted

19 upvotes 2 years ago

The user experienced high liver enzyme levels, possibly due to topical finasteride or supplements, and decided to stop using finasteride while continuing minoxidil. After stopping finasteride and supplements, liver levels returned to normal, suggesting finasteride or supplements might have been the cause.

community 3 months of topical minoxidil 5% and 1mg of oral finasteride

in Is this regrowth? 379 upvotes 9 months ago

The user experienced significant hair regrowth after three months of using topical minoxidil 5% and 1mg oral finasteride, along with addressing vitamin D and iron deficiencies. Some users expressed skepticism about the rapid results, while others congratulated the user on their progress.

community One Year Progress (Topical Fin/Min)

in Progress Pictures 154 upvotes 1 year ago

The user experienced significant hair regrowth over a year using topical finasteride (0.1%) and minoxidil (7%), along with Ketoconazole shampoo, and recently switched to dutasteride and plans to add oral minoxidil. They managed side effects like oily skin and itchiness with a corticosteroid and chose topical treatments initially to limit systemic exposure.

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Learn

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learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. Topical finasteride offers localized treatment with fewer systemic side effects than oral finasteride.

learn Cetirizine

Is topical cetirizine effective for androgenetic alopecia in women? Topical cetirizine is not an approved product and its use for female-pattern hair loss is off-label. The evidence is one small unblinded pilot study in mixed-sex patients and one randomized trial in 66 women where cetirizine was added to minoxidil; it is unproven on its own.

learn Estradiol

How does topical Estradiol compare to oral Estradiol in treating alopecia? Topical estradiol delivers hormone to the scalp with less systemic exposure, but evidence is thin and it is still a hormone. It needs a doctor's supervision, and people with estrogen-sensitive cancers must not use it without medical approval.

learn Glycerin

Does topical glycerin have any effect on hair thickness or follicle function? Topical glycerin primarily hydrates hair but does not increase thickness or follicle function.

learn L-cysteine

Can topical products with L-cysteine repair damaged hair or prevent breakage? Topical L-cysteine cannot effectively repair damaged hair or prevent breakage.

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