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Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability

research Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With an Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability

17 citations , June 2017 in “Journal of pharmaceutical sciences”

This study found that adapalene-loaded nanospheres in a hyaluronic acid gel enhanced skin penetration and were nonirritant, making them potentially suitable for treating acne on oily skin.

research Tolerability, acceptability, and reproducibility of topical STAR particles in human subjects

5 citations , April 2023 in “Bioengineering & Translational Medicine”

This study found that STAR particles, when applied to human skin, were well tolerated and highly acceptable at various pressures and with repeated daily use, suggesting they may provide a safe and effective method for enhancing drug delivery through the skin.

Tolerability of Hair Cleansing Conditioners: A Double-Blind Randomized Controlled Trial Evaluating Consumer Complaints to the U.S. Food and Drug Administration

research Tolerability of hair cleansing conditioners: a double-blind randomized, controlled trial designed to evaluate consumer complaints to the U.S. Food and Drug Administration

4 citations , March 2020 in “Cutaneous and ocular toxicology”

In this double-blind, randomized controlled study, researchers found that Wen by Chaz Dean Sweet Almond Mint Cleansing Conditioner was similarly tolerated compared to three other hair cleansing conditioners and was significantly better tolerated than salicylic acid shampoo or baby shampoo in terms of skin reactions.

research Tolerability of Six Months Indirect Cold (Physical) Plasma Treatment of the Scalp for Hair Loss

3 citations , November 2020 in “Journal of Drugs in Dermatology”

This study found that indirect treatment with cold atmospheric plasma showed promise for improving androgenetic alopecia in patients, laying the groundwork for longer trials to assess its efficacy.

research Tolerability and Adherence Problems in Patients on a Stable Dose of Methotrexate: Results of a Multicentre Survey

3 citations , December 2015 in “Musculoskeletal care”

This study found that many patients taking methotrexate for inflammatory arthritis tolerate significant side effects, but adherence to the medication still varies among individuals.

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community Efficacy and Tolerability of N-Acetyl-Cysteine for Treatment of The Early-onset Androgenetic Alopecia in Men

26 upvotes 4 years ago

N-Acetyl-Cysteine (NAC) was found to improve hair parameters in men with early-onset androgenetic alopecia, showing increased terminal hair count and decreased vellus hair count, with good tolerability. NAC, used alone or with minoxidil, may help due to its antioxidant properties, though its effectiveness can vary among individuals.

community Would a combination of low dose oral and topical finasteride theoretically give the best outcome?

in Finasteride/Dutasteride 5 upvotes 4 months ago

Using a combination of low-dose oral and topical finasteride, along with minoxidil, may effectively manage hair loss by targeting both systemic and local DHT. Users report positive experiences with this regimen, noting good tolerability and no worsening of hair condition.

community AH-001 another topical AR degrader beside GT20029, completed Phase I

8 upvotes 10 months ago

AH-001 is a new topical treatment designed to degrade androgen receptors, targeting the root cause of androgenetic alopecia without the side effects of oral treatments like finasteride. It has shown a strong safety profile and good local tolerability in early trials.

community Thoughts of this sub on Melatonin?

3 upvotes 1 year ago

Melatonin, gingko biloba, and biotin are effective for treating hair loss with good tolerability. Alternatives like dutasteride, minoxidil, and other peptides are also discussed.

community Amplifica AMP-303 study results are expected late this summer

16 upvotes 2 years ago

Results for Amplifica's AMP-303 hair loss treatment study are expected late summer 2024. The study, fully enrolled in Q1 2024, focuses on safety and tolerability.

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