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    Glossary Tight Junctions

    specialized cell connections that prevent molecule and ion passage

    Tight junctions, also known as occluding junctions or zonula occludens, are specialized connections between adjacent cells in epithelial and endothelial tissues. They create a seal that prevents the passage of molecules and ions through the space between cells, thereby maintaining the distinct environments on either side of the tissue layer. This is crucial for functions such as maintaining the blood-brain barrier and regulating the absorption of nutrients in the intestines.

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    1. The role of tight junctions in skin barrier function and dermal absorption Journal of controlled release · 2016 · 156 citations
    2. Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance 2016 · 26 citations
    3. Tight Junction barriers in human hair follicles – role of claudin-1 Scientific reports · 2018 · 39 citations
    4. 647 Alternative splicing factor Esrp1 controls homeostasis of skins by regulating barrier formation and function 2018
    5. Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway ˜The œAmerican journal of pathology · 2009 · 137 citations
    6. PSXIV-17 Examining Mammary Gland Transcriptomic Profiles Using Rna-Seq in Slick and Wild-Type Haired Holstein Cattle Under Tropical Conditions 2023
    7. The pattern recognition receptor toll-like receptor 3 regulates skin barrier homeostasis eScholarship (California Digital Library) · 2014
    8. Understanding the Characteristics of the Scalp for Developing Scalp Care Products Journal of Cosmetics Dermatological Sciences and Applications · 2021 · 7 citations
    9. LB1081 Three-dimensional imaging of tight junction-network across multiple layers of human epidermis by array tomography using backscattered electron-mode scanning electron microscopy Journal of Investigative Dermatology · 2019
    10. Tight junctions form a barrier in porcine hair follicles European journal of cell biology · 2015 · 21 citations
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