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    Glossary Tight Junctions

    specialized cell connections that prevent molecule and ion passage

    Tight junctions, also known as occluding junctions or zonula occludens, are specialized connections between adjacent cells in epithelial and endothelial tissues. They create a seal that prevents the passage of molecules and ions through the space between cells, thereby maintaining the distinct environments on either side of the tissue layer. This is crucial for functions such as maintaining the blood-brain barrier and regulating the absorption of nutrients in the intestines.

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    Research 30 of 1000+

    1. The role of tight junctions in skin barrier function and dermal absorption Journal of controlled release · 2016 · 156 citations
    2. Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance 2016 · 26 citations
    3. Tight Junction barriers in human hair follicles – role of claudin-1 Scientific reports · 2018 · 39 citations
    4. 647 Alternative splicing factor Esrp1 controls homeostasis of skins by regulating barrier formation and function 2018
    5. Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway ˜The œAmerican journal of pathology · 2009 · 137 citations
    6. PSXIV-17 Examining Mammary Gland Transcriptomic Profiles Using Rna-Seq in Slick and Wild-Type Haired Holstein Cattle Under Tropical Conditions 2023
    7. The pattern recognition receptor toll-like receptor 3 regulates skin barrier homeostasis eScholarship (California Digital Library) · 2014
    8. Understanding the Characteristics of the Scalp for Developing Scalp Care Products Journal of Cosmetics Dermatological Sciences and Applications · 2021 · 7 citations
    9. LB1081 Three-dimensional imaging of tight junction-network across multiple layers of human epidermis by array tomography using backscattered electron-mode scanning electron microscopy Journal of Investigative Dermatology · 2019
    10. Tight junctions form a barrier in porcine hair follicles European journal of cell biology · 2015 · 21 citations
    11. DHT deficiency perturbs the integrity of the rat seminiferous epithelium by disrupting tight and adherens junctions Folia Histochemica et Cytobiologica · 2011 · 27 citations
    12. Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity Cell reports · 2018 · 25 citations
    13. Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis 2012 · 47 citations
    14. Formation of the cornified envelope Experimental dermatology · 2005 · 3 citations
    15. TCF/Lef1-Mediated Control of Lipid Metabolism Regulates Skin Barrier Function Journal of Investigative Dermatology · 2011 · 22 citations
    16. Lentinula edodes (Shiitake) extract as a vitamin D receptor activator to enhance skin adaptogenic responses Scientific Reports · 2026
    17. Tea Polyphenol–Zinc Nanocomplexes Alleviate Diquat-Induced Liver and Small Intestine Oxidative Stress in C57BL/6 Mice Nanomaterials · 2025
    18. Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis Theranostics · 2024
    19. Testosterone Reduces Tight Junction Complexity and Down-regulates Expression of Claudin-4 and Occludin in the Endometrium in Ovariectomized, Sex-steroid Replacement Rats in Vivo · 2019 · 10 citations
    20. Drug delivery to the hair follicle : role of follicular tight junctions as a biological barrier and the potential for targeting clobetasol nanocarriers SciDok (Saarland University and State Library) · 2015
    21. The Fate of Epidermal Tight Junctions in the stratum corneum: Their Involvement in the Regulation of Desquamation and Phenotypic Expression of Certain Skin Conditions International Journal of Molecular Sciences · 2022 · 11 citations
    22. Identification and characterization of circRNAs in the skin during the wool follicle development of Aohan fine wool sheep Research Square (Research Square) · 2019
    23. 519 The role of the leaky gut in the development of alopecia areata 2019
    24. Lactiplantibacillus plantarum lysate isolated from green tea leaves alleviates the effects of Malassezia restricta on primary human scalp cells Research Square (Research Square) · 2025
    25. Claudin Expression Modulations Reflect an Injury Response in the Murine Epidermis Journal of Investigative Dermatology · 2007 · 9 citations
    26. The Role of Paracellular Transport in the Intestinal Absorption and Biopharmaceutical Characterization of Minoxidil Pharmaceutics · 2022 · 1 citations
    27. Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (Atelerix albiventris) Scientific reports · 2020 · 2 citations
    28. Effect of Minoxidil on Trabecular Outflow via the Paracellular Pathway 2020
    29. Transcriptome Profiling of Pilosebaceous Units in Male Androgenetic Alopecia Reveals Altered Junctional Networks Journal of Investigative Dermatology · 2021
    30. LB1076 Using the frog embryonic epidermis as a model to study desmosome function during development Journal of Investigative Dermatology · 2019