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research Thyroid Hormone Receptor Agonist Promotes Hair Growth in Mice

1 citations , February 2022 in “Clinical, Cosmetic and Investigational Dermatology”

In this study, researchers found that the thyroxine receptor agonist TDM10842 accelerated the onset of anagen, a hair growth phase, in C3H mice, potentially through activation of the Wnt/beta-catenin and Hedgehog pathways, with Pclaf playing a key role in this process.

research Thyroid receptor agonists for the treatment of androgenetic alopecia

19 citations , October 2009 in “Bioorganic & Medicinal Chemistry Letters”

This study found that a thyroid hormone receptor ẞ subtype-selective thyromimetic was effective in promoting hair growth in mouse and monkey models when applied topically.

research Cell type‐specific actions of thyroid hormones in nonalcoholic steatohepatitis and liver fibrosis

3 citations , January 2024 in “Liver International”

This study by Dr. Manka and colleagues reported that thyroid hormones play a significant role in regulating hepatic stellate cells, influencing liver fibrosis progression via TGFβ signaling. They found that TRα signaling might enhance scar-free tissue regeneration, offering potential pathways for targeted liver fibrosis treatments.

research Emerging pharmacotherapies for Androgenetic Alopecia

June 2026 in “Expert Opinion on Pharmacotherapy”

This article reviews emerging therapies for androgenetic alopecia, highlighting advances like androgen-receptor antagonists and improved minoxidil delivery that aim to enhance treatment efficacy and safety.

research Triclocarban, Triclosan, Bromochlorophene, Chlorophene, and Climbazole Effects on Nuclear Receptors: An in Silico and in Vitro Study

29 citations , October 2020 in “Environmental health perspectives”

This study found that several preservatives, including triclocarban and triclosan, showed potential endocrine-disrupting effects on various nuclear receptors in both in silico and in vitro models.

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community Most Promising Future Hair Loss Treatments In 2026

83 upvotes 2 weeks ago

Promising hair loss treatments in 2026 include GT20029, a topical androgen receptor degrader, and VDPHL01, an extended-release oral minoxidil, both offering safer alternatives with fewer side effects. Other treatments like sublingual minoxidil, OND-1, JW0061, TDM-105795, and AMP-303 are also being explored.

community Ray Peat: Testosterone Isn’t the Culprit, Prolactin and Cortisol Drive Hair Loss (2016)

in Research/Science 110 upvotes 11 months ago

Prolactin and cortisol are identified as key factors in hair loss, with stress hormones impacting hair shedding. Finasteride and minoxidil are effective treatments, while DHT's role and individual sensitivity are significant factors.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Can I take bicalutamide for hair loss as a man, but don’t want to transition?

in Treatment 4 upvotes 6 months ago

A 23-year-old man with hair loss, despite using dutasteride, oral minoxidil, and RU58841, is considering bicalutamide for regrowth but is concerned about feminization. Alternatives like topical estrogen, JXL069, and spironolactone are discussed, with suggestions to explore thyroid levels and other potential underlying conditions.

community Topical fin/min + microneedling 3 month results

36 upvotes 1 year ago

The conversation discusses hair loss treatments, specifically using topical finasteride and minoxidil combined with microneedling, along with supplements like collagen, vitamin C/D, and saw palmetto. The user also mentions using a DHT-blocking shampoo and experimenting with cold showers and contrast therapy for hair health.

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