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      learn Platelet-Rich Plasma

      growth factors taken from your blood and injected into your scalp to stimulate hair

      learn Azelaic Acid

      acid used for antimicrobial, anti-inflammatory and anti-androgenic properties

      learn Osteopontin

      signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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      What should I do 18M facing extreme hair thining and dandruff

      community What should I do 18M facing extreme hair thining and dandruff

      in General  161 upvotes 3 months ago
      An 18-year-old is experiencing severe hair loss and dandruff, feeling stressed and unable to commit to Minoxidil or handle finasteride side effects. They have tried natural oils, anti-hair fall shampoo, and consulted a dermatologist without success, and are seeking affordable treatment options.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.