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research Aromatase-independent testosterone conversion into estrogenic steroids is inhibited by a 5α-reductase inhibitor

44 citations , December 2005 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that testosterone is converted to estrogenic steroids in vitro without aromatase involvement, suggesting that combining 5α-reductase and aromatase inhibitors might reduce estrogenic steroids more completely in vivo.

research SAT-288 Successful Virilization of a PAIS Patient with a Missense Mutation In The Ligand-binding Domain Of The Androgen Receptor with Combined High-dose Testosterone and Aromatase Inhibitor

April 2019 in “Journal of the Endocrine Society”

This case report documents successful virilization, including penile length increase, in a boy with partial androgen insensitivity syndrome using high-dose testosterone combined with anastrozole.

Overexpression of Aldo-Keto Reductase 1C3 in LNCaP Cells Diverts Androgen Metabolism Towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride

research Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride

45 citations , January 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that overexpression of AKR1C3 in prostate cancer cells redirected androgen metabolism towards testosterone production, which facilitated cell proliferation, potentially reducing the effectiveness of finasteride treatment.

Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque¹

33 citations , January 1997 in “Endocrinology”

Testosterone was found to inhibit hair follicle epithelial cell proliferation in adult stumptailed macaques only when dermal papilla cells from bald scalps were present, and this effect was reversed by the antiandrogen RU 58841.

research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

19 citations , January 1997 in “Endocrinology”

This study observed that testosterone inhibits hair follicle epithelial cell proliferation in adult stumptailed macaques only when dermal papilla cells from bald scalps are present, with antiandrogen RU 58841 reversing this effect.

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Community Join

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community Akkermansia improves testosterone-induced hair growth inhibition.

4 upvotes 2 years ago

Akkermansia bacteria can improve hair growth inhibited by testosterone, and metformin may increase Akkermansia, which could help with hair loss related to aging, insulin resistance, and inflammation.

community What happens if you combine dutasteride and a aromataze inhibitor?

4 upvotes 7 years ago

Combining dutasteride and an aromatase inhibitor may increase testosterone levels significantly, potentially enhancing athletic performance but also posing health risks like elevated blood pressure and worsened cholesterol. The user is experimenting with dutasteride, anastrozole, minoxidil, and ketoconazole shampoo to manage hair loss and estradiol levels, while monitoring side effects and hormone levels.

community Take licorice to lower testosterone?

1 upvotes 9 years ago

Licorice is not recommended for hair loss as it inhibits hair growth and is a non-selective testosterone inhibitor. Alternatives like spironolactone are suggested for those considering hormonal treatments for hair loss.

community Finasteride doubled my testosterone & estrogen

in Chat 265 upvotes 10 months ago

Finasteride increased testosterone and estrogen, stopped hair loss, and promoted regrowth. Users discussed side effects like libido changes and considered adding minoxidil and aromatase inhibitors.

community Low dose spiro with 5ARI inhibitor

in Chat 2 upvotes 1 year ago

Spironolactone, finasteride, and dutasteride are discussed for hair maintenance, with concerns about testosterone and side effects like gynecomastia. Spironolactone is noted for use in both bodybuilding and hormone therapy, with low doses considered for minimizing side effects.

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Learn

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learn Ecklonia Cava

How does Ecklonia Cava help slow down hair loss in people with androgenetic alopecia? Ecklonia cava may slow hair loss by inhibiting the enzyme that converts testosterone to DHT.

learn Finasteride

Frontline, gold standard treatment for combatting androgenic alopecia

learn Dutasteride

Heavy duty finasteride that comes with higher risks

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Bicalutamide

a nonsteroidal anti-androgen, most commonly used orally for women

Could bicalutamide help trans women regrow hair lost to testosterone? No study has tested bicalutamide for hair regrowth in trans women. In cisgender women the only randomized trial found it added nothing to minoxidil, and it is an off-label prescription drug that requires liver monitoring.

learn Azelaic Acid

acid used for antimicrobial, anti-inflammatory and anti-androgenic properties

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