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      learn Minoxidil

      An essential vasodilator with some anti-androgenic effects, has excellent safety record

      learn Clascoterone

      a novel topical treatment that inhibits DHT on androgen receptors

      learn Dutasteride

      Heavy duty finasteride that comes with higher risks, but scalp injections seem safe and are gaining popularity

      learn Pyrilutamide

      highly targeted anti-androgen that might have minimal systemic effects

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      community Methods Of Staying Safe On Ru58841 - My 2 Cents

      in Research/Science  22 upvotes 6 months ago
      RU58841 is used topically to prevent hair loss by blocking DHT, with suggestions to drink grapefruit juice, take breaks, avoid microneedling, and use lower concentrations to reduce side effects. Users discuss applying it at night to minimize systemic absorption.

      community Anyone wanna try and interview the developers of RU?

      in Research/Science  84 upvotes 4 years ago
      The conversation discusses arranging an interview with the developers of RU58841 to clarify its safety and reasons for halted research, with some users expressing concerns about potential risks and others citing financial reasons for the discontinuation of studies. Specific treatments mentioned include RU58841, minoxidil, and finasteride.

      community Does ketoconazole reduce systemic DHT by much?

      in Treatment  6 upvotes 3 weeks ago
      Ketoconazole shampoo does not significantly reduce systemic or scalp DHT levels and is mainly used for its anti-fungal and anti-inflammatory effects. It is not a replacement for finasteride, which is recommended by some users despite concerns about side effects.

      community Keto shampoo and its impact on dht levels?

      in Progress Pictures  5 upvotes 3 weeks ago
      Ketoconazole shampoo does not significantly reduce systemic or scalp DHT levels and is considered a mild topical antiandrogen. Users discuss its use for scalp health rather than DHT reduction, with some preferring alternatives like dutasteride over finasteride due to perceived side effects.

      community Kintor Phase 2 Results released KX-826 (pyrilutamide)

      in Research/Science  447 upvotes 2 years ago
      Kintor Pharmaceutical's Phase 2 results with the drug Pyrilutamide, a potential alternative to 5-ARI drugs like Finasteride and Dutasteride but without the side effects. It could be used in combination with other topical treatments such as Minoxidil. The safety of the drug has been demonstrated in 6 months of use, however there are still questions about long term efficacy and systemic absorption.