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research Neuronal plasticity of the “brain–skin connection”: stress-triggered up-regulation of neuropeptides in dorsal root ganglia and skin via nerve growth factor-dependent pathways

66 citations , July 2007 in “Journal of Molecular Medicine”

This study in mice demonstrated that stress or nerve growth factor injection increases sensory neuron activity related to skin innervation, suggesting a strong connection between stress perception and neurogenic skin inflammation.

research OBESITY-RELATED FACTORS INVOLVED IN ENDOPLASMIC RETICULUM STRESS INDUCTION IN ADIPOCYTES

January 2015 in “Durham e-Theses (Durham University)”

This study found that glucose starvation and hypoxia are physiological triggers of ER stress in in vitro differentiated adipocytes, rather than high concentrations of saturated fatty acids, cholesterol, or proinflammatory cytokines.

research 131 Patient experiences with alopecia areata: Sentiment analysis of survey responses

July 2024 in “Journal of Investigative Dermatology”

Alopecia areata causes negative emotions and stress due to hair loss and emotional triggers.

research Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity

November 2025 in “Cell”

This study found that acute stress can cause rapid hair loss by triggering necrosis in hair follicle cells and initiating autoimmunity, revealing a mechanism where stress-induced nerve activity leads to tissue damage and immune system activation.

research Co‐regulatory mechanisms and potential markers of oxidative stress‐related genes in vitiligo and alopecia areata

5 citations , August 2024 in “Skin Research and Technology”

This study found that KLB and EIF3C are important in the progression of vitiligo and AA, suggesting they could be biomarkers and early diagnostic targets.

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Community Join

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community Acute shedding episodes. Had telogen effluvium last year. Remission for a few months(thought I was over the shedding stuff 🥲). Now if I have any major stress days, THAT day I get a major shed and a few days after.

4 upvotes 1 year ago

The user experiences immediate hair shedding linked to stress, unlike typical telogen effluvium, and is seeking answers. A suggestion was made to use spironolactone and topical minoxidil to address potential DHT-related shedding.

community Intermittent fasting reduces hair growth?!? :(

35 upvotes 1 year ago

Intermittent fasting may inhibit hair growth by triggering a stress response that affects hair-follicle stem cells. Some users believe genetics and DHT play a larger role in hair loss, and treatments like Minoxidil and Finasteride are mentioned as ineffective for some.

community Could creatine trigger faster hairloss?

29 upvotes 2 years ago

Creatine is reported by many to increase hair loss, though no scientific evidence supports this. Some use finasteride and minoxidil to manage hair loss, while others avoid creatine due to personal experiences.

community Has anyone tried nicotinamide serum for inflammatory hair loss.

3 upvotes 1 year ago

Nicotinamide serum is discussed for its potential benefits in reducing inflammation related to hair loss. One user combines it with minoxidil for hair growth.

community My personal thoughts on DHT. belive it or not

1 year ago

The conversation discusses a personal theory on the role of DHT in stress and reproduction, suggesting it converts testosterone for reproductive traits. The discussion includes skepticism and mentions individual differences in physiology and neurochemistry.

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Learn

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learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Epidermal Growth Factor

learn Vitamin B5

Is Vitamin B5 beneficial for people experiencing stress-related or nutritional hair loss? Vitamin B5 is not proven to help with stress-related or nutritional hair loss.

learn Vitamin B6

Is Vitamin B6 helpful for stress-related or hormonal hair loss? Vitamin B6 may support overall health but lacks strong evidence for preventing hair loss.

learn Lavender

Is lavender effective for hormonal hair loss or just stress? Lavender may help with stress-related hair loss but has limited evidence for hormonal hair loss.

learn Hair Transplant

How can I stop hair loss related to hair transplants? Adopt a nutritious diet, manage stress, and consult a specialist for tailored treatments.

learn PP405

Got small bald patches they say are from stress? PP405 sprays could help bring them back to life. PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier; its registered Phase 2 trial (NCT06393452) tested it once daily in 78 adults with pattern hair loss, for safety and tolerability. It is not approved, not for sale, and has not been studied in alopecia areata or stress-related shedding.

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