research Steroidomics for highlighting novel serum biomarkers of testosterone doping
This study found that monitoring endogenous steroid metabolites in serum may improve the detection of testosterone doping by highlighting promising biomarkers.
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5 / 1000+ resultsresearch The 5α-reductase inhibitor finasteride reduces opioid self-administration
This study found that finasteride reduced opioid self-administration in zebrafish and rats without affecting pain relief, suggesting steroidogenic pathways may offer new treatment avenues for opioid use disorder.
research OR20-01 Machine Learning-based Steroid Metabolome Analysis In Women With Polycystic Ovary Syndrome Reveals Three Distinct Androgen Excess Subtypes With Different Metabolic Risk Profiles.
In this study, distinct androgen excess subtypes were identified in women with PCOS, with the adrenal androgen excess cluster showing significantly higher rates of insulin resistance and type 2 diabetes, suggesting 11-oxygenated androgens as potential drivers of metabolic risk.
research Urinary steroid metabolome shows adrenal, gonadal, and neuroactive steroid dysregulation in adolescents with depression
In this study, adolescents with depressive symptoms were found to have higher urinary excretion rates of certain steroid metabolites, including corticosterone and adrenal hormones, and a specific metabolite ratio was identified as a potential biomarker for distinguishing these patients from healthy controls.
research Design and Validation of a Sensitive Multisteroid LC-MS/MS Assay for the Routine Clinical Use: One-Step Sample Preparation with Phospholipid Removal and Comparison to Immunoassays
This study found that LC-MS/MS assays provided more reliable and precise steroid measurements in human serum compared to traditional immunoassays, particularly at lower concentrations.
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