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research Pharmacokinetics of Modified Slow-Release Oral Testosterone over 10 Days in Normal Men with Experimental Hypogonadism

June 2011

In this study, oral testosterone administered three times daily normalized serum testosterone levels in men with experimentally induced hypogonadism over nine days and significantly reduced SHBG.

research Pharmacokinetics of Modified Slow-Release Oral Testosterone Over 9 Days in Normal Men With Experimental Hypogonadism

7 citations , May 2012 in “International Journal of Andrology”

This study found that an oral testosterone formulation normalized serum testosterone levels and significantly reduced SHBG in men with experimentally induced hypogonadism after nine days of treatment, suggesting potential efficacy for testosterone deficiency.

research Pharmacokinetics of 2 Novel Formulations of Modified-Release Oral Testosterone Alone and With Finasteride in Normal Men With Experimental Hypogonadism

6 citations , November 2010 in “International Journal of Andrology”

In a clinical trial, this study found that a modified slow-release oral testosterone formulation improved pharmacokinetics, delaying serum testosterone peaks and reducing serum DHT compared to immediate-release formulations, especially when combined with finasteride.

research Optimisation of microstructured biodegradable finasteride formulation for depot parenteral application

6 citations , February 2016 in “Journal of Microencapsulation”

This study found that injectable finasteride microspheres provided a sustained drug release with a minimal initial burst in albino rabbits compared to oral suspension.

research Polycystic ovary syndrome

989 citations , August 2007 in “The Lancet”

This article reviews the clinical features, diagnostic criteria, and possible genetic and environmental influences of polycystic ovary syndrome but provides no new research findings.

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community 3 months on 0,5 dutasteride and 2,5 oral minoxidil / 22 years

147 upvotes 5 months ago

A 22-year-old experienced significant hair regrowth in three months using 0.5 mg dutasteride and 2.5 mg oral minoxidil, with no side effects. Users discussed the effectiveness of oral minoxidil, the necessity of dutasteride for maintaining hair, and concerns about potential side effects.

community 2.5 months on Oral Minoxidil (2.5mg) + Finasteride (1mg) - Early signs of progress? And also estrogen level change

10 upvotes 2 months ago

The user has been using 2.5mg oral minoxidil and 1mg finasteride daily for 2.5 months, noticing increased hair density and new hair growth. There is concern about elevated estradiol levels, possibly due to finasteride, but no significant side effects have been reported yet.

community Topical Dutasteride (Switching from Oral) Proven results

23 upvotes 5 years ago

Switching from oral to topical dutasteride may reduce side effects like anxiety and depression while maintaining hair health. Combining it with minoxidil, Nizoral, and dermarolling could be effective for hair preservation.

community Does finasteride decrease free testosterone?

in Research/Science 186 upvotes 1 year ago

Finasteride may decrease free testosterone by increasing SHBG, potentially causing side effects like reduced libido and hormonal changes. Some find it effective for hair loss, while others experience negative effects.

community Is there a known amount of fin that can reduce serum DHT by only around 25% over the longer term?

4 upvotes 5 years ago

The conversation discusses finding a finasteride dosage that reduces DHT by about 25% to minimize side effects, with considerations for topical versus oral formulations. Alternatives like dutasteride mesotherapy and topical treatments are explored, with concerns about systemic absorption and potential impacts on athletic performance and hormone levels.

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