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Research

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research Genetic determinants of skin ageing: a systematic review and meta-analysis of genome-wide association studies and candidate genes

3 citations , February 2025 in “Journal of PHYSIOLOGICAL ANTHROPOLOGY”

This systematic review and meta-analysis found 30 genetic loci associated with skin ageing phenotypes, noting shared biological pathways in aspects like pigmentation and wrinkling; researchers suggest further studies targeting the same SNP across populations could clarify these associations.

research Pmg-1 and Pmg-2 constitute a novel family of KAP genes differentially expressed during skin and mammary gland development

22 citations , August 1999 in “Mechanisms of Development”

This study identified two novel genes, pmg-1 and pmg-2, expressed in various skin and gland tissues and potentially involved in the differentiation of epithelial cells in epidermal appendages.

research Using WGCNA (weighted gene co-expression network analysis) to identify the hub genes of skin hair follicle development in fetus stage of Inner Mongolia cashmere goat

16 citations , December 2020 in “PloS one”

In this study, WNT10A was identified as a key gene in the development and maturation of skin hair follicles in fetal Inner Mongolian cashmere goats.

research Skin transcriptomic and selection signature analyses identify ASIP as a key gene in cattle coat color determination

2 citations , April 2025 in “Frontiers in Genetics”

This study investigated the genetic basis of coat color variation in cattle using skin transcriptome and whole-genome analyses, identifying the ASIP gene as a significant determinant that is differentially expressed and under strong positive selection in black and brown cattle breeds.

research Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction

87 citations , July 2009 in “Journal of Cell Science”

The researchers found that corneodesmosin is crucial for maintaining skin barrier integrity and hair follicle architecture in mice, with its deletion leading to severe skin and hair abnormalities.

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Community Join

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community Is it possible to transplant mice skin into human body?

in Transplants 47 upvotes 10 months ago

Transplanting mice skin to humans is not feasible due to immune rejection, but some suggest genetic modification or immune suppression could make it possible. Xenograft hair transplants are discouraged.

community New study suggests hair regrowth on wounded and bald skin may be possible

4 upvotes 7 years ago

Hair regrowth on wounded and bald skin may be possible by activating the sonic hedgehog gene, leading to hair regrowth in mice. The findings are promising but may not directly apply to humans.

community How legit is the skin issues (loss of collagen, wrinkles, under eye cricles etc) with minoxodil?

7 upvotes 8 years ago

Minoxidil may cause facial bloat, wrinkles, and dark circles, with some users experiencing these side effects quickly. Finasteride can cause painful ejaculations and watery semen, but concerns about penis shrinkage are generally unfounded.

community My Idea for a possible new hairloss treatment

53 upvotes 6 years ago

Exploring a potential hair loss treatment using the enzyme AKR1C2 to locally reduce DHT levels. Challenges include enzyme delivery through the skin and high production costs, with gene therapy or stem cells suggested as future alternatives.

community Very high testosterone and estradiol on finasterid 1 mg. Am I cooked?

3 upvotes 9 months ago

A 29-year-old male on 1 mg Finasteride for 3 months has experienced a significant increase in testosterone and estradiol levels, with no major side effects except slightly oilier skin and increased emotional sensitivity. The user is concerned about these hormonal changes and seeks advice, as their general practitioner is not knowledgeable about the issue.

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Clinics

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All 69 clinic results →

Learn

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learn Scalp Micropigmentation

How long does scalp micropigmentation take to heal? Scalp micropigmentation typically takes 7-14 days to heal fully.
Does scalp micropigmentation hurt? Scalp micropigmentation typically causes minimal discomfort, often described as light scratching.

learn Hair Transplant

Hair transplantation moves DHT-resistant follicles from a donor area (back and sides of the scalp) into thinning or bald areas. The transplanted hair is generally permanent, though surrounding native hair can keep thinning.

How long does recovery take after a hair transplant? Recovery after a hair transplant typically takes 7 to 14 days for initial healing.
What is a hair transplant? A hair transplant is a surgical procedure that relocates hair follicles to areas of thinning.
Is a hair transplant safe? Hair transplants are generally safe when done by qualified professionals in sterile conditions.

learn Vitamin D

vitamin you should probably be taking for general health might also help your hair a little

learn Microneedling

technique to create small wounds in skin to activate collagen production and hair growth

learn Peppermint

herb and oil thought to stimulate skin and hair

learn Epidermal Growth Factor

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Experts

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36
SMP Specialist
Noelle Skin
Nice, France

Noelle Skin