271 citations
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May 2019 in “Cells” This review discusses the therapeutic potential of MSC-derived secretomes for treating degenerative and inflammatory diseases, reporting no new clinical results but highlighting their proposed mechanisms and advantages over direct MSC transplantation.
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March 2023 in “Pharmaceutics” This study found that PBMCsec has anti-fibrotic effects on mouse and human skin scars by regulating pro-fibrotic gene expression and inhibiting myofibroblast differentiation and elastic fiber breakdown.
In this case report, a 48-year-old woman with kerion celsi showed improvement with a regimen including antifungal, bacterial, and adjunctive treatments, though the specific role of mesenchymal stromal cell secretome could not be isolated from the other therapies.
May 2026 in “International Journal of Molecular Sciences” This study found that plucked hair follicles can serve as a practical and scalable source for regenerative medicine, as researchers successfully isolated and expanded keratinocytes and mesenchymal stem cells for potential cell-based and cell-free therapies, demonstrating significant wound-healing bioactivity in vitro.
October 2025 in “International Journal of Cell and Biomedical Science” In this study, the application of human umbilical cord mesenchymal stem cell secretome significantly increased hair follicle count in fluconazole-induced alopecia in rats, although changes in epidermal thickness were not significant, suggesting a novel approach for hair restoration.