27 citations
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September 2012 in “Dermatologic Clinics”
This review outlines a systematic method for diagnosing hair loss and presents no new findings; the authors emphasize the importance of biopsy in cicatricial alopecia cases.
In this research, an optimized protocol was developed for dissociating human scalptissue to produce high-quality single-cell suspensions suitable for single-cell RNA sequencing, aimed at studying the transcriptomics of human hair follicles.
This study observed that platelet-rich gel for scalp defect reconstruction was more cost-effective and less painful but resulted in poorer hair growth compared to the external tissue expansion technique.
Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.
Dutasteride may not be effective for everyone due to underlying issues, suggesting scalp biopsies for further diagnosis. Users discuss using higher doses of dutasteride, topical treatments, minoxidil, and pyrilutamide for hair loss management.
Dutasteride takes 1-3 months to affect scalp DHT levels, not just a week. The prostate absorbs Dutasteride faster than the scalp due to different vascular networks and enzyme densities.
Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.
Higher doses of dutasteride reduce scalp DHT more effectively than finasteride, but have diminishing returns after 3mg daily and may cause more side effects. Combining dutasteride with topical minoxidil can enhance results, but using both finasteride and dutasteride together is unnecessary.
Can a hair transplant cover scars?Clinics say hair transplants can often cover scalp scars, but graft survival in scar tissue is less predictable and needs careful assessment.