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research Role of S-Palmitoylation by ZDHHC13 in Mitochondrial function and Metabolism in Liver

59 citations , May 2017 in “Scientific reports”

This study found that ZDHHC13 deficiency in mice is associated with abnormal liver function, lipid metabolism issues, and impaired mitochondrial function, highlighting ZDHHC13's regulatory role in liver metabolism.

research Protein S-Palmitoylation as Potential Therapeutic Target for Dermatoses

December 2025 in “Biomolecules”

This study reviews the emerging role of protein S-palmitoylation in dermatology, highlighting its impact on skin functions like inflammation and barrier maintenance, and evaluating its potential as a therapeutic target for skin disorders such as alopecia and psoriasis.

research Mice with Alopecia, Osteoporosis, and Systemic Amyloidosis Due to Mutation in Zdhhc13, a Gene Coding for Palmitoyl Acyltransferase

73 citations , June 2010 in “PLoS Genetics”

This study identified that a deficiency in the palmitoyl transferase enzyme, due to a mutation in the Zdhhc13 gene, led to severe physiological abnormalities in mice, including skin, bone, and systemic amyloid issues.

research Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13 -Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation

16 citations , June 2015 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that DHHC13 is crucial for hair anchoring and skin barrier function, with its deficiency in Zdhhc13(skc4) mice leading to cyclic alopecia and skin abnormalities due to cornifelin deficiencies.

research Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene

22 citations , December 2015 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that mice with a mutation in the Zdhhc13 gene exhibited increased susceptibility to skin cancer, highlighting a potential protective role of palmitoyl acyltransferase in skin carcinogenesis.

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Community Join

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community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community There's hope for us, boys! Don't despair!

205 upvotes 1 day ago

Some people find baldness attractive, and preferences vary. Treatments like Minoxidil and finasteride are mentioned, but personal acceptance and confidence are emphasized.

community That's quite funny if you as me

40 upvotes 6 days ago

Finasteride use and its potential side effects, including erectile dysfunction and post-finasteride syndrome (PFS), with discussions on lifestyle factors and the influence of anxiety. Some users argue that PFS is not well-documented, while others share personal experiences of adverse effects.

community What's the point of finasteride if dutasteride exists?

43 upvotes 1 week ago

Finasteride is effective for hair loss with fewer side effects and quicker clearance compared to dutasteride, which is more potent but has a longer half-life and potentially more side effects. Users suggest starting with finasteride and considering dutasteride only if more hair retention is needed and side effects are manageable.

community What's the proper way to use a derma stamp?

104 upvotes 2 weeks ago

A user is seeking advice on using a derma stamp for hair loss treatment, alongside minoxidil and finasteride. Recommendations include cleaning the scalp, using alcohol or hypochlorous acid for sterilization, starting with a needle length of 0.5mm, and stamping once a week.

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Learn

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learn Botox

What’s the science behind Botox injections for androgenetic alopecia? Small published studies and a 2025 meta-analysis report hair-count gains from scalp botulinum toxin injections, but nearly all of them lack control groups, and reviewers of the same literature call the evidence low-quality; the treatment is off-label and not approved for hair loss anywhere.

learn Glycerin

What’s the difference between vegetable glycerin and synthetic glycerin in hair products? Vegetable glycerin is plant-derived, while synthetic glycerin is petroleum-based, but both are chemically identical.

learn Hyaluronic Acid

What’s the difference between using hyaluronic acid as a serum on the scalp versus taking it as a supplement? A serum sits on the scalp surface. Oral hyaluronic acid has small trials on facial wrinkles, none on the scalp or hair.

learn Salicylic acid

What’s the difference between using salicylic acid for scalp exfoliation versus regular shampooing? Salicylic acid loosens dead skin cells in the scalp's outer layer, while regular shampoo mainly washes away surface oil and dirt.

learn Pyrithione Zinc

What’s the difference between pyrithione zinc and salicylic acid when treating scalp buildup? Pyrithione zinc is an antifungal that slows the yeast linked to dandruff, while salicylic acid loosens and sheds scale; both are permitted US over-the-counter dandruff ingredients. Zinc pyrithione has been banned in EU cosmetics since 2022 because it is classified as toxic for reproduction.

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