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GlossaryS100 Proteins (S100 family)

calcium-binding proteins involved in cell regulation and signaling

S100 Proteins are a family of calcium-binding proteins involved in various intracellular and extracellular functions, such as regulation of protein phosphorylation, enzyme activities, and cell growth and differentiation. They are implicated in several diseases, including cancer, neurodegenerative disorders, and inflammatory conditions, making them significant both in basic biological research and clinical diagnostics.

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research Gene Expression of Mouse S100A3, a Cysteine-Rich Calcium-Binding Protein, in Developing Hair Follicle

40 citations, November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

S100A3 protein is crucial for hair shaft formation in mice.

research Identification of Long Noncoding RNAs in Mouse Hair Follicle Stem Cells Using Computational Methods

July 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

Scientists found new and known long non-coding RNAs in mouse hair follicle stem cells that may be important for stem cell function and could be targets for cancer treatment.

research Blockade of S100A3 Activity Inhibits Murine Hair Growth

1 citations, January 2015 in “Genetics and Molecular Research”

Stopping S100A3 activity slows down hair growth in mice.

research Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa

22 citations, August 2021 in “Frontiers in medicine”

Immune cells in Hidradenitis suppurativa become more inflammatory and may be important for treatment targets.

research Desmoplastic Melanoma Presenting as an Alopecic Patch in a Young Patient

June 2023 in “JAAD Case Reports”

A man had a rare skin cancer that looked like a bald spot.

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community What the hell happened in my family genes?

f0llicly_challenged in Chat 116 upvotes 8 months ago

A user is frustrated about early balding despite older male relatives retaining hair into old age. Another user plans to start finasteride soon to address their hair thinning.

community Anyone else’s loved ones just blatantly gaslight you over your hair ?

MisterS1997 in Finasteride/Dutasteride 196 upvotes 1 year ago

User discusses resentment towards people who dismissed their hair loss concerns and continued to do so even after a specialist confirmed it. Others share similar experiences and discuss the impact of hair loss on self-esteem and societal perceptions.

community This is Brad Pitt @ 59 years old

1leeranaldo in Satire 2656 upvotes 1 year ago

The conversation is about Brad Pitt's hair and whether he has had a hair transplant or used finasteride. Some users believe that his good genetics and lifestyle choices are responsible for his hair, while others think he may have had cosmetic procedures or used hair loss treatments.

community Next month marks 2 years on Dutasteride. When does it start working?

Foreign_Fondant_2880 in Finasteride/Dutasteride 36 upvotes 8 months ago

A user has been on dutasteride for nearly 2 years with no improvement in hair loss, expressing frustration. Other users suggest checking for other health conditions, getting bloodwork, and considering stopping TRT or trying finasteride.

community Rare Non responder to Finasteride, Dutasteride, and oral minoxidil

hairthishairthat in Minoxidil 78 upvotes 11 months ago

A user did not respond to finasteride, dutasteride, and oral minoxidil for hair loss after four years of treatment and is considering scalp micropigmentation (SMP). Other users suggest the hair loss pattern may indicate alopecia areata and recommend seeing a dermatologist.

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