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GlossaryROCK inhibitor (Rho-associated kinase inhibitor)

blocks enzymes involved in cell contraction and motility

A ROCK inhibitor, also known as a Rho-associated kinase inhibitor, is a type of drug that blocks the activity of Rho-associated kinases (ROCKs). These enzymes play a crucial role in various cellular functions, including contraction, motility, proliferation, and apoptosis. By inhibiting ROCKs, these drugs can help treat conditions like hypertension, glaucoma, and even promote hair growth in cases of alopecia by improving blood flow and reducing inflammation.

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Short-Term Rho-Associated Kinase Inhibitor Treatment Accelerates Primary Keratinocyte Growth Without Affecting the Stem Cell Population

research Short-Term Rho-Associated Kinase Inhibitor Treatment Accelerates Primary Keratinocyte Growth Without Affecting the Stem Cell Population

November 2022 in “Journal of Investigative Dermatology”

Short-term treatment with ROCKi increases skin cell growth without changing stem cell features.

research Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632

16 citations, March 2021 in “Frontiers in cell and developmental biology”

A new method using Y-27632 improves the growth and quality of human hair follicle stem cells for tissue engineering and therapy.

research Boosting and Rescuing Epidermal Superior Population from Fresh Keratinocyte Cultures

15 citations, August 2013 in “Stem Cells and Development”

The method increases stem-like cells for better skin regeneration.

research Targeting the Hippo/YAP/TAZ Signalling Pathway: Novel Opportunities for Therapeutic Interventions into Skin Cancers

7 citations, August 2022 in “Experimental dermatology”

Blocking YAP/TAZ could be a new way to treat skin cancer.

research Small Molecules and Small Molecule Drugs in Regenerative Medicine

51 citations, November 2013 in “Drug Discovery Today”

Small molecule drugs show promise for advancing regenerative medicine but still face development challenges.

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community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.