19 citations
,
February 2018 in “Nutrients” This review discusses the relationship between zinc deficiency and skin disorders, emphasizing zinc transporters' roles, but it reports no new clinical results; the authors highlight potential benefits of regulating zinc levels via transporters.
11 citations
,
January 2020 in “BMC pediatrics” This case report identified two new SLC39A4 mutations in twin patients with acrodermatitis enteropathica, suggesting that different mutations in this gene may lead to varying clinical manifestations of the disorder.
75 citations
,
May 2013 in “Journal of the American Academy of Dermatology” This review examines skin symptoms, diagnosis, and treatment of zinc deficiency in children, proposing a classification system but reporting no new clinical results.
5 citations
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April 2013 in “Nasza Dermatologia Online” This study reports no new clinical results on oral zinc therapy for acrodermatitis enteropathica but provides demographic data and symptom prevalence among thirty affected children.
December 2025 in “Cureus” In this report, successful management of inherited acrodermatitis enteropathica, a zinc absorption disorder due to an SLC39A4 gene defect, was demonstrated in an infant through zinc supplementation.
August 2025 in “International Journal of Research in Dermatology” This case report highlights an atypical presentation of acrodermatitis enteropathica in an 18-year-old male, exhibiting symptoms like erythrokeratoderma variabilis with a positive response to high-dose oral zinc, underscoring the importance of considering zinc deficiency in unusual skin conditions.
195 citations
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February 2005 in “Journal of biological chemistry/The Journal of biological chemistry” This study shows that ZIP7 is a functional zinc transporter in mammalian cells, facilitating the movement of zinc from the Golgi apparatus to the cytoplasm.
46 citations
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May 2020 in “Cureus” This review analyzes the molecular and genetic roles of zinc, its connection to diarrheal disease, dietary recommendations, and the impacts of zinc deficiency on health, but reports no new data.
30 citations
,
June 2006 in “British journal of dermatology/British journal of dermatology, Supplement” In this study, oral zinc sulphate was found to cause hair hypopigmentation and significantly inhibit eumelanogenesis in mice.
11 citations
,
October 2015 in “Journal der Deutschen Dermatologischen Gesellschaft” This study observed that women post-bariatric surgery may be at increased risk for dermatological signs of malnutrition during subsequent pregnancies, highlighting the need for dermatologists to recognize these early symptoms.
5 citations
,
July 2017 in “Women & Health” This study found that nursing women in the West Bank of Palestine who lived in cities and consumed energy beverages had higher blood zinc levels.
2 citations
,
May 2021 in “Case reports in dermatological medicine” This report describes a 28-year-old male with type 1 diabetes who presented with acrodermatitis enteropathica symptoms, highlighting potential challenges in blood glucose control linked to zinc deficiency.
This study found that γδ T cells play a role in regulating stromal behavior, influencing the composition and vascularity of fibrotic tissues during the foreign body response.
August 2024 in “Turkish Journal of Pediatric Disease” This case report details a 5-month-old infant with acrodermatitis enteropathica, linked to zinc deficiency from total parenteral nutrition, who showed improvement using zinc spray and cream, contrasting with typical literature outcomes.
September 2022 in “JAMC. Journal of Ayub Medical College, Abbotabad, Pakistan/Journal of Ayub Medical College” This case study reports that zinc supplementation significantly improved the symptoms of Acrodermatitis Enteropathica in a 12-year-old boy, emphasizing the importance of early diagnosis and treatment compliance.
January 2022 in “Dermatology Review” This study found that patients with chronic kidney disease-associated pruritus had elevated serum levels of interleukin 31, suggesting a possible role of this cytokine in the condition.
January 2021 in “Middle East journal of applied sciences” This article discusses the widespread issue of zinc deficiency affecting plant, animal, and human health, and reports no new clinical results; the authors emphasize the need for adequate zinc availability in agriculture and nutrition.
April 2020 in “Journal of evolution of medical and dental sciences” This report reviews the clinical presentation and genetic aspects of a case of acrodermatitis enteropathica in a one-year-old child but provides no new clinical findings.
December 2016 in “Journal of Evolution of Medical and Dental Sciences” This case report highlights that inherited zinc deficiency can persist into adulthood and emphasizes the importance of selecting optimal chelating agents to improve oral zinc bioavailability.
117 citations
,
August 1999 in “Nature Genetics” March 2026 in “World Rabbit Science” This study found that overexpression and knockdown of DKK4 influence genes involved in hair follicle growth and development in Angora rabbits and identified specific SNPs in DKK4 associated with wool quality, notably showing that the TT/GG haplotype combination relates to higher fibre diameters.
April 2012 in “The FASEB Journal” In this study, researchers observed that knocking down the LPA 4 receptor in zebrafish embryos led to vascular and lymph vessel development abnormalities, including edema and decreased heartbeats.
1 citations
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February 2023 in “Pharmaceutics” This article reviews cell proteomic footprinting technology and its application in improving the authentication and quality control of cell-based immunotherapeutics, without providing new clinical results.
July 2026 in “Research Square” October 2025 in “Frontiers in Medicine” In this case report, a 10-month-old ethnic minority infant from Xinjiang with acrodermatitis enteropathy improved clinically and biochemically after zinc supplementation, underscoring the importance of early genetic testing for SLC39A4 mutations and individualized zinc therapy in managing this disorder.
February 2025 in “Journal of Investigative Dermatology” The ZIP13 variant is linked to abnormal hair quality.
January 2023 in “Open journal of pediatrics” In this case report, a 7-month-old girl with suspected acrodermatitis enteropathica and severe dermatitis experienced a tragic outcome despite zinc treatment, highlighting the challenges of diagnosing and managing this rare genetic disorder.
18 citations
,
March 2015 in “Journal of Endocrinological Investigation” This study found that ZP4 expression was highest among PCOS patients with regular menstrual cycles, which may be linked to mature follicle presence, but no correlation with clinical indices was observed.
6 citations
,
July 2025 in “Cancer Medicine” This study reported that ZSYY001, a nanoparticle formulation of polymeric micellar paclitaxel, showed promising antitumor activity and was safe and well-tolerated in preclinical models and a phase I trial, without acute hypersensitivity reactions at doses up to 390 mg/m².
April 2016 in “Journal of Investigative Dermatology” This study found that the peptide derivative beta-Ala-Pro-Dab-NHbenzyl may reduce wrinkles and sebum production in human skin by inhibiting dipeptidyl peptidase 4, suggesting potential for acne and skin inflammation treatment.