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Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Lower doses of treatments for hirsutism and acne in PCOS are effective and cause fewer side effects.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Fibroblasts, cells usually linked to tissue repair, also help regenerate various organs and their ability decreases with age. Turning adult fibroblasts back to a younger state could be a new treatment approach.

The document concludes that understanding how adult stem and progenitor cells move is crucial for tissue repair and developing cell therapies.

Methionine restriction works better than betaine for treating CBS deficiency symptoms in mice.

The HOXC13 gene affects different hair proteins in cashmere goats in varied ways and is controlled by a feedback loop and other factors.

A patch made from human lung fibroblast material helps heal skin wounds effectively, including diabetic ulcers.

Mongolian gerbils heal wounds differently than mice, with unique protein levels and gene expression that affect skin repair.

CD201+ fascia progenitors are essential for wound healing and could be targeted for treating skin conditions.

Proactive monitoring and management are essential to maximize the benefits of Trastuzumab Deruxtecan while minimizing serious side effects.

Saw palmetto may improve urinary symptoms with fewer sexual side effects compared to some medications.

Cinnamaldehyde helps bone healing initially but may slow healing later unless combined with DHT treatment.

Some cancer and immune system drugs can cause serious side effects, including heart, lung, nerve, and organ damage, which need careful monitoring and management.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

Different types of fibroblasts play various roles in diseases and healing, and more research on them could improve treatments.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.

Low-oxygen conditions and ECM degradation products increase the healing abilities of perivascular stem cells.

The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.