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    Did you mean Wnt pathway activator?
    Glossary Wnt pathway activator

    stimulates cell growth and development through Wnt signaling

    A Wnt pathway activator is a substance or molecule that stimulates the Wnt signaling pathway, a crucial cell communication system involved in regulating cell growth, development, and differentiation. This pathway plays a significant role in hair follicle development and regeneration, making Wnt activators potential therapeutic agents for conditions like alopecia (hair loss).

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    1. Vitamin B12 Activates the Wnt-Pathway in Human Hair Follicle Cells by Induction of <i>beta</i>-Catenin and Inhibition of Glycogensynthase Kinase-3 Transcription Journal of Cosmetics, Dermatological Sciences and Applications · 2011 · 4 citations
    2. Escin Activates Canonical Wnt/β-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3β in Cultured Human Dermal Papilla Cells Current Issues in Molecular Biology · 2023
    3. Wnt/β-catenin signaling pathway activates melanocyte stem cells in vitro and in vivo Journal of Dermatological Science · 2016 · 45 citations
    4. Low‐level laser activates Wnt/β‐catenin signaling pathway‐promoting hair follicle stem cell regeneration and wound healing: Upregulate the expression of key downstream gene Lef 1 Skin Research and Technology · 2024 · 2 citations
    5. Pre-aggregation of scalp progenitor dermal and epidermal stem cells activates the WNT pathway and promotes hair follicle formation in in vitro and in vivo systems Stem Cell Research & Therapy · 2019 · 17 citations
    6. MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway Journal of Cell Biology · 2014 · 103 citations
    7. LncRNA H19 Overexpression Activates Wnt Signaling to Maintain the Hair Follicle Regeneration Potential of Dermal Papilla Cells Frontiers in Genetics · 2020 · 12 citations
    8. Wnt/β-Catenin Signaling Pathway Targeting Androgenetic Alopecia: How Far Can We Go Beyond Minoxidil and Finasteride? Journal of Medicinal Chemistry · 2025
    9. Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture Frontiers in Pharmacology · 2020 · 23 citations
    10. Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis Development · 2011 · 59 citations
    11. Activating Wnt/β-catenin signaling pathway for disease therapy: Challenges and opportunities Pharmacology & Therapeutics · 2018 · 140 citations
    12. Abstract 1026: A non-apoptotic function for Mcl-1 as an activator of canonical Wnt signaling in keratinocytes Cancer Research · 2010
    13. High-throughput screening of small molecule Wnt/β-catenin activators for hair and nail growth Communications Biology · 2026
    14. Topical application of the Wnt/<i>β</i>-catenin activator methyl vanillate increases hair count and hair mass index in women with androgenetic alopecia Journal of Cosmetic Dermatology · 2016 · 20 citations
    15. Hair growth–promoting effects of Enz_MoriL on human dermal papilla cells through modulation of the Wnt/β-Catenin and JAK-STAT signaling pathways Archives of dermatological research · 2024
    16. Molecular Mechanisms and Targeted Therapeutics in Androgenetic Alopecia: From Signaling Pathways to Regenerative Approaches Premier journal of science. · 2026
    17. Insulin Promotes Corneal Nerve Repair and Wound Healing in Type 1 Diabetic Mice by Enhancing Wnt/β-Catenin Signaling American Journal of Pathology · 2020 · 15 citations
    18. Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity 2023
    19. Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity 2023
    20. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012 · 85 citations
    21. Isoxazole 9 (ISX9), a small molecule targeting Axin, activates Wnt/β‐catenin signalling and promotes hair regrowth British Journal of Pharmacology · 2023 · 11 citations
    22. Limonin, a Component of Immature Citrus Fruits, Activates Anagen Signaling in Dermal Papilla Cells Nutrients · 2022 · 3 citations
    23. Non-thermal atmospheric pressure plasma activates Wnt/β-catenin signaling in dermal papilla cells Scientific Reports · 2021 · 24 citations
    24. ISX9, a small molecule targeting Axin, activates Wnt/β-catenin signaling and promotes hair regrowth 2022
    25. Knockdown of miR-361-5p promotes the induced activation of SHF-stem cells through FOXM1 mediated Wnt/β-catenin pathway in cashmere goats Animal Biotechnology · 2024 · 1 citations
    26. mTOR signaling in hair follicle and hair diseases: recent progress Frontiers in medicine · 2023
    27. Wound healing in development Birth Defects Research · 2012 · 29 citations
    28. Deciphering principles of morphogenesis from temporal and spatial patterns on the integument Developmental Dynamics · 2015 · 19 citations
    29. Decision letter: A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning 2017
    30. New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence Journal of Investigative Dermatology · 2012 · 68 citations